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IV isotonic bicarbonate
IV isotonic bicarbonate restores acid-base balance by increasing serum bicarbonate concentration to counteract metabolic acidosis.
IV isotonic bicarbonate restores acid-base balance by increasing serum bicarbonate concentration to counteract metabolic acidosis. Used for Metabolic acidosis requiring rapid pH correction, Acute kidney injury with severe acidemia.
At a glance
| Generic name | IV isotonic bicarbonate |
|---|---|
| Sponsor | VA Office of Research and Development |
| Drug class | Alkalinizing agent |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Metabolic Disorders |
| Phase | Phase 3 |
Mechanism of action
This intravenous formulation delivers bicarbonate ions in an isotonic solution to correct systemic acidemia. It works by increasing the bicarbonate buffer system, which neutralizes excess hydrogen ions and raises blood pH. This is particularly useful in acute metabolic acidosis where rapid correction is needed without fluid overload.
Approved indications
- Metabolic acidosis requiring rapid pH correction
- Acute kidney injury with severe acidemia
Common side effects
- Hypernatremia
- Hypokalemia
- Alkalosis (overcorrection)
- Phlebitis at infusion site
Key clinical trials
- Prevention of Serious Adverse Events Following Angiography (PHASE3)
- PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization (PHASE3)
- Bicarbonate in Patients With Out-of-hospital Cardiac Arrest (PHASE2)
- Tolerability and Efficacy of RJX in Patients With COVID-19 (PHASE1, PHASE2)
- Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery (PHASE2)
- Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease (PHASE4)
- Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV isotonic bicarbonate CI brief — competitive landscape report
- IV isotonic bicarbonate updates RSS · CI watch RSS
- VA Office of Research and Development portfolio CI