Last reviewed · How we verify
Safety of Low Dose Intravenous Contrast 64 Multi-Detector Computed Tomography Scanning in Patients With Chronic Kidney Disease
The purpose of this study is to show that the use of low volume iso-osmolar non-ionic radio contrast medium (30 cc) in a thoracic CT Scanning procedure in a selected group of patients with chronic kidney disease (CKD) will avoid contrast induced nephropathy (CIN) in comparison to a similar group of patients with CKD who receive no contrast medium..
Details
| Lead sponsor | VA Greater Los Angeles Healthcare System |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 50 |
| Start date | 2008-09 |
| Completion | 2017-11-20 |
Conditions
- Chronic Kidney Disease
- Pulmonary Embolism
- Renal Artery Stenosis
- Pulmonary Cancer
Interventions
- Low Volume iso-osmolar non-ionic radio contrast medium
- Acetylcysteine Inhalation
- Sodium Bicarbonate Solution
- 64-MDCT Scanning
Primary outcomes
- Peak Serum Creatinine Level — Up to 72 hours after intervention
The peak serum creatinine increase over baseline within 72 hours after intervention is the outcome variable. This variable is used for comparison between two groups, as well as for safety monitoring in the intervention group (25% increase is the upper threshold)
Countries
United States