{"id":"iv-isotonic-bicarbonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypernatremia"},{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Alkalosis (overcorrection)"},{"rate":null,"effect":"Phlebitis at infusion site"}]},"_chembl":{"chemblId":"CHEMBL2106975","moleculeType":"Small molecule","molecularWeight":"100.11"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This intravenous formulation delivers bicarbonate ions in an isotonic solution to correct systemic acidemia. It works by increasing the bicarbonate buffer system, which neutralizes excess hydrogen ions and raises blood pH. This is particularly useful in acute metabolic acidosis where rapid correction is needed without fluid overload.","oneSentence":"IV isotonic bicarbonate restores acid-base balance by increasing serum bicarbonate concentration to counteract metabolic acidosis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:17:26.257Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metabolic acidosis requiring rapid pH correction"},{"name":"Acute kidney injury with severe acidemia"}]},"trialDetails":[{"nctId":"NCT01467466","phase":"PHASE3","title":"Prevention of Serious Adverse Events Following Angiography","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2013-10-07","conditions":"Acute Renal Failure, Kidney Disease, Coronary Artery Disease","enrollment":5177},{"nctId":"NCT02980003","phase":"PHASE3","title":"PrevenTion of Contrast-inducEd nephroAThy With urinE Alkalinization","status":"COMPLETED","sponsor":"G. d'Annunzio University","startDate":"2015-03","conditions":"Acute Kidney Injury, Contrast Media Reaction","enrollment":240},{"nctId":"NCT02303548","phase":"PHASE2","title":"Bicarbonate in Patients With Out-of-hospital Cardiac Arrest","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2014-10","conditions":"Cardiac Arrest, Metabolic Acidosis","enrollment":50},{"nctId":"NCT04708340","phase":"PHASE1, PHASE2","title":"Tolerability and Efficacy of RJX in Patients With COVID-19","status":"UNKNOWN","sponsor":"Reven Pharmaceuticals, Inc.","startDate":"2021-03-25","conditions":"COVID-19, Acute Respiratory Distress Syndrome, SARS-CoV-2","enrollment":237},{"nctId":"NCT00484354","phase":"PHASE2","title":"Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2006-05","conditions":"Kidney Failure, Acute, Renal Replacement Therapy","enrollment":123},{"nctId":"NCT02476526","phase":"PHASE4","title":"Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease","status":"COMPLETED","sponsor":"VA Greater Los Angeles Healthcare System","startDate":"2008-09","conditions":"Chronic Kidney Disease, Pulmonary Embolism, Renal Artery Stenosis","enrollment":50},{"nctId":"NCT00514150","phase":"PHASE3","title":"Effect of Sodium Bicarbonate Solution in Decreasing the Incidence of Contrast Induced Nephropathy (CIN)","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2007-08","conditions":"Contrast Induced Nephropathy","enrollment":265}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"IV isotonic bicarbonate","genericName":"IV isotonic bicarbonate","companyName":"VA Office of Research and Development","companyId":"va-office-of-research-and-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"IV isotonic bicarbonate restores acid-base balance by increasing serum bicarbonate concentration to counteract metabolic acidosis. Used for Metabolic acidosis requiring rapid pH correction, Acute kidney injury with severe acidemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}