VA Office of Research and Development

Quick facts

Marketed products

• Acetazolamide + supplemental oxygen + PAP therapy · Pulmonary/Respiratory, High-Altitude Medicine
  This combination therapy reduces periodic breathing and improves oxygenation in high-altitude pulmonary edema (HAPE) and related conditions by suppressing respiratory alkalosis, providing supplemental oxygen, and applying positive airway pressure.
• Aspirin treatment · Cardiovascular; Pain management; Inflammation
  Aspirin irreversibly inhibits cyclooxygenase (COX) enzymes, reducing the production of thromboxane A2 and other prostaglandins to decrease platelet aggregation and inflammation.
• Blinded clopidogrel · Metabolic
• Buspirone + PAP therapy · Psychiatry / Sleep Medicine
  Buspirone acts as a serotonin 5-HT1A receptor agonist to reduce anxiety, while PAP (positive airway pressure) therapy mechanically maintains airway patency during sleep to treat obstructive sleep apnea.
• Cessation-Phase Varenicline
• Clopidogrel treatment · Cardiovascular
  Clopidogrel inhibits platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.
• Diuretic initiation or augmentation
• High dose erythropoietin · Hematology
  High-dose erythropoietin stimulates erythroid progenitor cells in bone marrow to increase red blood cell production and hemoglobin levels.
• hydrocodone/APAP · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• hydrocodone/APAP w placebo PRN · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Inhaled Fluticasone Propionate · Respiratory/Pulmonology
  Fluticasone propionate is a corticosteroid that reduces airway inflammation by binding to glucocorticoid receptors and suppressing inflammatory cytokine production.
• Injectable subcutaneous buprenorphine · Pain Management; Substance Use Disorder
  Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to reduce pain and suppress opioid withdrawal symptoms.
• Low dose erythropoietin · Hematology
  Low-dose erythropoietin stimulates erythroid progenitor cells in the bone marrow to increase red blood cell production.
• Medication optimization
  Medication optimization is a clinical practice framework aimed at improving therapeutic outcomes by systematically reviewing, adjusting, and personalizing drug regimens for individual patients.
• Miralax-Gatorade Prep · Gastroenterology
  Miralax-Gatorade Prep is an osmotic laxative combined with an electrolyte solution that draws water into the bowel to promote bowel evacuation.
• Motivation-Phase Nicotine Mini-Lozenge · Addiction Medicine / Smoking Cessation
  Nicotine binds to nicotinic acetylcholine receptors in the brain to reduce cravings and withdrawal symptoms during smoking cessation.
• Motivation-Phase Varenicline
• Mupirocin calcium ointment, 2%
• Nasal Povidone Iodine
• Nicotine rescue method · Addiction Medicine / Smoking Cessation
  Nicotine acts as an agonist at nicotinic acetylcholine receptors in the central and peripheral nervous system to reduce cravings and withdrawal symptoms in tobacco dependence.
• Open Label (OL) Paroxetine · Psychiatry / Neurology
  Paroxetine selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.
• opioid dose escalation · Pain Management
  Opioid dose escalation is a clinical practice of incrementally increasing opioid medication doses to maintain analgesic efficacy in patients with chronic pain.
• Oral Albuterol Extended Release
• Oxygen + PAP therapy · Respiratory/Pulmonary
  Oxygen therapy combined with positive airway pressure (PAP) delivers supplemental oxygen while maintaining continuous airway pressure to improve oxygenation and ventilation in patients with respiratory insufficiency.
• Personalized Smoking Cessation Pharmacotherapy
• placebo with hydrocodone/APAP PRN · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Pluvicto · Oncology
• Pneumovax · Infectious Disease
• recombinant human BNP(1-32) · Cardiovascular
  Recombinant human BNP(1-32) is a truncated B-type natriuretic peptide that activates natriuretic peptide receptors to promote vasodilation, reduce cardiac preload and afterload, and inhibit the renin-angiotensin-aldosterone system.
• Sublingual buprenorphine with naloxone
• TDAP · Other
• Thienopyridine (open-label) · Cardiovascular
  Thienopyridines inhibit platelet aggregation by blocking the P2Y12 adenosine diphosphate receptor on platelets.
• Topical Chlorhexidine, 4%
• Trazodone + PAP therapy · Psychiatry / Sleep Medicine
  Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) that increases serotonin availability, combined with positive airway pressure (PAP) therapy to mechanically maintain open airways during sleep.
• Vancomycin with Taper/Pulse · Infectious Disease
  Vancomycin inhibits bacterial cell wall synthesis by binding to D-Ala-D-Ala peptidoglycan precursors, and a taper/pulse dosing regimen modulates exposure to reduce toxicity while maintaining efficacy.
• Zolpidem + PAP therapy · Sleep Medicine / Neurology
  Zolpidem enhances GABAergic inhibition in the central nervous system to promote sleep, while PAP (positive airway pressure) therapy mechanically maintains airway patency during sleep.

Phase 3 pipeline

• Augmenting: Antidepressant + Aripiprazole · Psychiatry / Mental Health
  Aripiprazole augments antidepressant therapy by acting as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, enhancing monoaminergic neurotransmission in depression.
• Augmenting: Antidepressant + Bupropion-SR · Psychiatry / Mental Health
  Bupropion-SR augments antidepressant therapy by inhibiting norepinephrine and dopamine reuptake, addressing residual depressive symptoms in patients with incomplete response to initial antidepressant monotherapy.
• Chlorthalidone (CTD) · Cardiovascular
  Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.
• Inactive Substance
  An inactive substance serves as a control or placebo with no pharmacological activity.
• IV isotonic bicarbonate · Critical Care / Metabolic Disorders
  IV isotonic bicarbonate restores acid-base balance by increasing serum bicarbonate concentration to counteract metabolic acidosis.
• Non biologically active gel
  Non biologically active gel does not have a known mechanism of action.
• Soy Supplement · Women's Health
  Soy supplements may help alleviate menopausal symptoms and improve bone density by mimicking the effects of estrogen in the body.
• Standard bismuth quadruple therapy · Gastroenterology
  Bismuth subsalicylate has antimicrobial properties that help treat and prevent ulcers and gastroesophageal reflux disease (GERD).
• standard statin monotherapy · Cardiovascular
  Standard statin monotherapy works by inhibiting HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway.
• Switching: Bupropion-SR · Psychiatry
  Bupropion-SR is a norepinephrine-dopamine reuptake inhibitor, which increases the levels of these neurotransmitters in the brain.

Phase 2 pipeline

• 150-day taper prednisone
• Cal-Mag Butyrate · Gastroenterology
  Cal-Mag Butyrate is a calcium and magnesium supplement with butyrate, which may help maintain healthy gut bacteria and support bone health.
• CORT108297
• Degarelix & Relugolix · Oncology
  Degarelix and Relugolix are GnRH receptor antagonists that inhibit the production of gonadotropin-releasing hormone, leading to a decrease in testosterone levels.
• Endocalyx · Other
• Full Dose MDMA
• Goserelin, Histrelin, Leuprolide & Triptorelin · Oncology
  Goserelin, Histrelin, Leuprolide, and Triptorelin are gonadotropin-releasing hormone (GnRH) agonists that work by mimicking the action of natural GnRH to suppress the production of sex hormones.
• Ibrutinib, Acalabrutinib, Zanubrutinib
• Mifepristone Oral Tablet [Korlym]
• NG-Monomethyl-L-Arginine
• NIC5-15
• Opioid Analgesics
• Resistant Potato Starch
• Testosterone and standard NMES
• Testosterone Patches
• TTI-0102

Phase 1 pipeline

• Active Iomazenil · Neurology
  Competitive antagonist of the central benzodiazepine receptor
• Antioxidant cocktail
• APLA12
• Celecoxib plus Calcitriol
• Co-Analgesic Therapy
• Fecal Microbial transplant Capsules
• Fecal Microbial Transplant Enema
• Natesto testosterone intranasal gel

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• VA Office of Research and Development portfolio CI brief
• VA Office of Research and Development pipeline updates RSS