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PRN","slug":"hydrocodone-apap-w-placebo-prn","phase":"marketed","mechanism":"Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.","indications":["Moderate pain (marketed combination indication)"],"catalyst":""},{"name":"opioid dose escalation","genericName":"opioid dose escalation","slug":"opioid-dose-escalation","phase":"marketed","mechanism":"Opioid dose escalation is a clinical practice of incrementally increasing opioid medication doses to maintain analgesic efficacy in patients with chronic pain.","indications":["Chronic pain management in opioid-tolerant patients","Cancer pain","Severe chronic non-cancer pain"],"catalyst":""},{"name":"placebo with hydrocodone/APAP PRN","genericName":"placebo with hydrocodone/APAP PRN","slug":"placebo-with-hydrocodone-apap-prn","phase":"marketed","mechanism":"Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception, while acetaminophen (APAP) inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.","indications":["Moderate pain (acute or chronic pain conditions)"],"catalyst":""}],"recentEvents":[],"realNews":[{"url":"https://news.google.com/rss/articles/CBMiXEFVX3lxTFB1N2d4NnYwN0JiU181Tm9vV0dUM1c1NWVMUHNCdlZFVmRSZXpmRFp3TnBQUVJXYnFYV1VlNVBIZXU0TzY4bE5BNTd4NGpIT21aYlZHMy1qSW1HWDFH?oc=5","date":"2026-04-06","type":"pipeline","source":"BioSpace","summary":"Layoff Tracker: BioNTech Will Close Singapore Plant, Affecting 85 Employees - BioSpace","headline":"Layoff Tracker: BioNTech Will Close Singapore Plant, Affecting 85 Employees","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMi0wJBVV95cUxPSkx5VHgxbGpTY0g1YXoyUDYwMDllbWxkd1pWZGZBYjJHbVhONUpXWHZMdDhrZ1RFRmxvZVAyVkRNUUUtZFFweGNUQXllby1IdnhkUkpZSUNRcmJIdlNaaEU1eGZHVFBjMmw2MlRlQ0t4NmpsWC1xQ18tUXNiU2RXMzN0amsyaG9UR1J1TnZJZTA3M3pjbjhuaG9KRVYwUWNyMlVnRjdRVFVwQkFUUUNNTEhhcE9VcXdvUHBud0plWERQZTAwOEJ4VjFEdFk4OEVud2tXY2tmRHA3TUJNVlc4cy1TXzVBQ3ZfbkpXc1FiTTlfME5SREJSemw0cGpwTExQTFhoWlFXYmpjcnRHOVk3ckR3czJvTEp5MU9aeFFkTk1ueE9vQ0k1NTd4MUJFNWRKVmdHM0tIek1PTk9mdV8xZ21ibDNHUTBYd0dpdGRTQUZvbUk?oc=5","date":"2026-03-30","type":"regulatory","source":"Barchart.com","summary":"Spinal Cord Injury Pipeline 2026: Latest FDA Approvals, Clinical Trials, and Emerging Therapies Assessment By DelveInsight | StemCyte, NervGen Pharma, VA Office of Research and Development, Kessler - ","headline":"Spinal Cord Injury Pipeline 2026: Latest FDA Approvals, Clinical Trials, and Emerging Therapies Assessment By DelveInsig","sentiment":"positive"},{"url":"https://news.google.com/rss/articles/CBMib0FVX3lxTE9hSGV3QkRSN21hRFdnWGYtUnZacFpFVTRrYUN3em5XS0d0ZncxZGkteXc3aDBhMG93bHNTWkhzLVJtZjhQRU4zMWR0ekFBRXNLdmZxSFljdW5YQjVPV3ZMYkVFenBoakExeE11dzZRSQ?oc=5","date":"2026-03-02","type":"pipeline","source":"Virginia Business","summary":"Virginia secures $12 billion pharma investments with rapid site readiness in 2025 - Virginia Business","headline":"Virginia secures $12 billion pharma investments with rapid site readiness in 2025","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMiswFBVV95cUxPYmZqWFcyYnZXdjU3Q2s2bnVOY2lMMlZVeWs1VUVtaUVrWk14MTNhd3dpVWxGU1pqb2JHMmxORW5XbDV2MTlQS1VfYnFrUnp1VE12LWRXUWtnUEFnUFNkbTl5bGgyODFtOFVaNjc0eWhGNlVUczFRUHJvRDlvTVR2eWlZMHdJbnZPdEJGZXJsS0VwSTlSczE4bktqRVFlcnZjdHZKcTAtR3FZNnphUHhhU3FFMA?oc=5","date":"2026-01-30","type":"pipeline","source":"Military.com","summary":"From Lizard Venom to Ozempic: How VA Research Changed Medicine - Military.com","headline":"From Lizard Venom to Ozempic: How VA Research Changed Medicine","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMinwFBVV95cUxOcW1pS2dxWi1fM2xiLVFwUmRsWlpVdjBkLUl5Y2ZlOTl0MGJ4Vk5tYUdqVmYyeUYwQTJEbWlaWnkzWE52XzIwU3ozUkIwckhYMUFUSkctMVphVGhNaDU2enhVOFBIbWxQcHRaX3ZUWUlVeFprSzZzREVNd25Wa2xKT3JqajRydlp5YUJGemVPd2N2R3BkcEJvc3lTZUtUaXc?oc=5","date":"2025-10-09","type":"regulatory","source":"UVA Today","summary":"UVA poised to benefit from AstraZeneca’s new Albemarle manufacturing site - UVA Today","headline":"UVA poised to benefit from AstraZeneca’s new Albemarle manufacturing site","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMiyAFBVV95cUxQSS03R040UFl3TExsTUVCVHN2eFpnVXg3MmRqNFI2UkdvWG5yUndNa0dXZEhNR3p2X0RycGxCcjdCOVNUVFJpWDFIT2hLZGFhdjJqeUJoalRRTW14LUwwNUFCWUtIMXpuaHNaZlVtUjdEV3J5VWFfOWp0M2wyR2xpNWJyZ0FzWXAwYnNvRlhrX0lNN0U2OHJaN0xybUlVZDhDRDVOQmtSRVU4SW5Od0UtQVROeTJ6RkRmSmhqRVFTTDRRZEZ5clc2SA?oc=5","date":"2025-07-22","type":"pipeline","source":"WSLS","summary":"Pharmaceutical company selects Virginia for multi-billion-dollar manufacturing center - WSLS","headline":"Pharmaceutical company selects Virginia for multi-billion-dollar manufacturing center","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMipgFBVV95cUxPREstT2FtR0RVOFhqVjk5dXpqMHViU0dWcGhXWm1NYUJNWlpFaDNLa3FQbWFGazVTaldsckhtUnVNSGNxY09jcVpIcUE3UGpfTWk2YVNjaUg5VlNTcjlVZUNKM3BrSnRHelloN1NwRkgxQkNnalN2R1pUQzM1TlI3VEpFZTJaYkVlV19jYkxwcHE0Z3cyOUxaTVFPMUxEVGFKRWdCZXRR0gGrAUFVX3lxTE9teGpkUm5DVEY5QlJlRzc2Sk9fR3hsNktkQl9rM3ltZzFzc2E5WncwZVdqOS1QWFU5TkdrQUMxQkI3SVR0cjVBSFdWdDdqZ3lPcGJwWUVTamNYS0ZVVDJqNHlhZGVEQ3Z4S0pDZGtoT2JldG9ZcEIxNlU1SlpmNEIyeEgwUzQwdmpVNENFeWpEbDV3U3VQcDVmSnB1QXVLcDZySlZBdVFwcE05RQ?oc=5","date":"2025-07-22","type":"pipeline","source":"CNBC","summary":"AstraZeneca to invest $50 billion in the U.S. as pharma tariffs weigh - CNBC","headline":"AstraZeneca to invest $50 billion in the U.S. as pharma tariffs weigh","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMiwgFBVV95cUxOUzRZX3puLVNCNVZxd0Y0U0MxUXpBb2lfdEVZUFNjR1lkNUFnOEw5M1k5NDJGcWFHQThoQVJGWEtFXzdPRnJYc3F0X29hcUVtVGxBRVRGZWI5YmRSRVl0UnVYNDAzSVNwRlNMbnVoX2FvNzRtM3BDRlQzMFlSMU9nemc0bWZNQ2JveE5VSG9XVkRjTTRYTWRSRHZUb0kxbjlNLTUzUmFXVUswY0JON0Z2YjA3c1BhcThYRHNaTzdTYWdidw?oc=5","date":"2025-07-22","type":"pipeline","source":"WTOP","summary":"AstraZeneca chooses Virginia for its largest-ever R&D and manufacturing investment - WTOP","headline":"AstraZeneca chooses Virginia for its largest-ever R&D and manufacturing investment","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMi1AFBVV95cUxQWnR5VmJWYmpRUjNfcU8wSUtDTldmdXIxVzJVMTVpbWxHcmxVTVhHVWRwLWFtamwwckNUWHZaWHA1NHJ2N0VSVkQzZWE4R3ExSnVVU1FnVDZTbjhGN0lHQlNCS1BWSWNTTlRuZEx4YVRlRm4yc291cDZWS1BxZzhoRFRQQlJxa3ZkZzExeUQ0Ymx3SVlwWGdsNG5nR0RDM0dGV25wUnRyczR2ckM1VVE3UDd5ZTZNbmw2eklNMkI3eEpJQUg2ZUJxY3Z5MzZZck1JNTYzWQ?oc=5","date":"2025-07-22","type":"pipeline","source":"Virginia Mercury","summary":"AstraZeneca to build its largest-ever manufacturing facility in Virginia, creating hundreds of jobs - Virginia Mercury","headline":"AstraZeneca to build its largest-ever manufacturing facility in Virginia, creating hundreds of jobs","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMi4AFBVV95cUxOODZhQ2o0VktJZHQ3YTRWN3dXUG94TGJTSGJOWEJvbzJubDFZdjh6YnN6M0RXRjFiZ19rMjdxd2dMX2dNdWgzM1VKUWFGaktKRDBCRkdiWEszQkZQS19JRC1vZDJXR3ZpWFV4VVFKM1hfOUprVzJnd3JaLThaeDRuLUdZM2ZYUXhfX1huaWljaUlYV2FzMEZseURfaUpEY0FmMlZZdkVPSGFDSkJCMW9ULWhYWFlPVUcyQWVmS0h3YnFBMVpYQjVCQ3I1WG1RUzUtc3BOb19OSXJsYjJuYjlYSw?oc=5","date":"2025-07-22","type":"pipeline","source":"Reuters","summary":"AstraZeneca unveils $50 billion US investment as pharma tariff threat looms - Reuters","headline":"AstraZeneca unveils $50 billion US investment as pharma tariff threat looms","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMiogFBVV95cUxQY2YzRDFQZkUyV2tPQkRmS25lLXJyLU1UcDBxdW9MejN6MERSOHNFbnVFbk02TGxfLW1OaDhQX0ZRbnpKUDdIYjQ3ZnBpSUp4dVZKSjRNMVJOX09kMloxbHozU2xWOVU5cURwREpQYkVIRzJJcjNCai05M3VoWHBxb0l0b1p0eFBrempQRFJmTW10dXRSa0RaRlBsdHZFSGhCeHc?oc=5","date":"2025-07-21","type":"pipeline","source":"BioPharma Dive","summary":"AstraZeneca grows US presence with $50B in spending plans - BioPharma Dive","headline":"AstraZeneca grows US presence with $50B in spending plans","sentiment":"neutral"},{"url":"https://news.google.com/rss/articles/CBMixgFBVV95cUxOSDJ2NDR2YnE0OFZBeUgxUzJmMWZNVFdUX2xtZ1FwRnU5a0Z2am5lb3dQbzhRazFNc01pTTdOajBFOXNCQWpWR0JLMzJIdnBfSkpoZkxlM0lkWWk1Z0dnX1ppbm9jREtWc2RHT3BBc0xYVXhPM0lQdTA4UUNVY2NBX2hVVHFZQXJTd1NudTFpa0hobW5ycHlxWm1MVkdHZHNuT2N6RjRTaHdTZURlZjJNN0FweDJaUWliOTlNcVpCYmRPOVZjNHc?oc=5","date":"2020-05-07","type":"trial","source":"VA.gov Home | Veterans Affairs","summary":"VA Research works with industry, other partners to launch COVID-19 clinical trials - VA.gov Home | Veterans Affairs","headline":"VA Research works with industry, other partners to launch COVID-19 clinical trials - VA.gov Home | Veterans Affairs","sentiment":"neutral"}],"patents":[],"drugCount":55,"phaseCounts":{"marketed":36,"phase_1":2,"phase_2":6,"phase_3":10,"discontinued":1},"enrichmentLevel":2,"visitCount":2,"keyCompetitors":[],"therapeuticFocus":[],"financials":null,"yahoo":null}