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Chlorthalidone (CTD)
Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.
Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure. Used for Hypertension, Edema associated with congestive heart failure, renal disease, or hepatic cirrhosis.
At a glance
| Generic name | Chlorthalidone (CTD) |
|---|---|
| Also known as | CTD |
| Sponsor | VA Office of Research and Development |
| Drug class | Thiazide-like diuretic |
| Target | Sodium-chloride cotransporter (NCC) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
By blocking the sodium-chloride cotransporter in the kidney's distal convoluted tubule, chlorthalidone increases urinary sodium and water excretion, leading to decreased intravascular volume and reduced peripheral vascular resistance. This results in antihypertensive effects. Chlorthalidone is a long-acting thiazide-like diuretic with a longer half-life and greater potency compared to hydrochlorothiazide.
Approved indications
- Hypertension
- Edema associated with congestive heart failure, renal disease, or hepatic cirrhosis
Common side effects
- Hypokalemia
- Hyperuricemia
- Hyperglycemia
- Hyponatremia
- Ototoxicity (at high doses)
- Photosensitivity
Key clinical trials
- Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension (PHASE4)
- Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients with Essential Hypertension
- Diuretic Comparison Project (PHASE3)
- Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorthalidone (CTD) CI brief — competitive landscape report
- Chlorthalidone (CTD) updates RSS · CI watch RSS
- VA Office of Research and Development portfolio CI