{"id":"chlorthalidone-ctd","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Ototoxicity (at high doses)"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL1055","moleculeType":"Small molecule","molecularWeight":"338.77"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By blocking the sodium-chloride cotransporter in the kidney's distal convoluted tubule, chlorthalidone increases urinary sodium and water excretion, leading to decreased intravascular volume and reduced peripheral vascular resistance. This results in antihypertensive effects. Chlorthalidone is a long-acting thiazide-like diuretic with a longer half-life and greater potency compared to hydrochlorothiazide.","oneSentence":"Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:44:55.596Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure, renal disease, or hepatic cirrhosis"}]},"trialDetails":[{"nctId":"NCT06041529","phase":"PHASE4","title":"Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension","status":"ACTIVE_NOT_RECRUITING","sponsor":"Yuhan Corporation","startDate":"2023-10-18","conditions":"Essential Hypertension","enrollment":198},{"nctId":"NCT06282549","phase":"","title":"Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients with Essential Hypertension","status":"ACTIVE_NOT_RECRUITING","sponsor":"Yuhan Corporation","startDate":"2022-06-08","conditions":"Essential Hypertension","enrollment":1219},{"nctId":"NCT02185417","phase":"PHASE3","title":"Diuretic Comparison Project","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2016-06-15","conditions":"Hypertension","enrollment":20723},{"nctId":"NCT00353652","phase":"PHASE4","title":"Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2005-01","conditions":"Hypertension","enrollment":166}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CTD"],"phase":"phase_3","status":"active","brandName":"Chlorthalidone (CTD)","genericName":"Chlorthalidone (CTD)","companyName":"VA Office of Research and Development","companyId":"va-office-of-research-and-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure. Used for Hypertension, Edema associated with congestive heart failure, renal disease, or hepatic cirrhosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}