Who are Chlorthalidone (CTD)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lozol, Zaroxolyn, Combipres, CHLORTHALIDONE, Metolazone Oral Tablet, Metolazone Tablets.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-15 · How we verify

Chlorthalidone (CTD) — Competitive Intelligence Brief

Chlorthalidone (CTD) (Chlorthalidone (CTD)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

phase 3 Thiazide-like diuretic Sodium-chloride cotransporter (NCC) Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Chlorthalidone (CTD) (Chlorthalidone (CTD)) — VA Office of Research and Development. Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Chlorthalidone (CTD) TARGET	Chlorthalidone (CTD)	VA Office of Research and Development	phase 3	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Metolazone Oral Tablet	Metolazone Oral Tablet	University of Virginia	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)
Metolazone Tablets	Metolazone Tablets	NHS Greater Glasgow and Clyde	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2028-03-26 — Combipres · 9066936 · US
2030-02-04 — Combipres · 9169238 · US
2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

Eurofarma Laboratorios S.A. · 1 drug in this class
Farma de Colombia SA · 1 drug in this class
Hospices Civils de Lyon · 1 drug in this class
NHS Greater Glasgow and Clyde · 1 drug in this class
University of North Carolina, Chapel Hill · 1 drug in this class
University of Virginia · 1 drug in this class
VA Office of Research and Development · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Chlorthalidone (CTD) — Competitive Intelligence Brief. https://druglandscape.com/ci/chlorthalidone-ctd. Accessed 2026-05-15.

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