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Metolazone Tablets

NHS Greater Glasgow and Clyde · FDA-approved active Small molecule

Metolazone Tablets is a Thiazide-like diuretic Small molecule drug developed by NHS Greater Glasgow and Clyde. It is currently FDA-approved for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease. Also known as: metolazone.

Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.

Metolazone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes to reduce blood volume and blood pressure. Used for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.

At a glance

Generic nameMetolazone Tablets
Also known asmetolazone
SponsorNHS Greater Glasgow and Clyde
Drug classThiazide-like diuretic
TargetNa-Cl cotransporter (NCC)
ModalitySmall molecule
Therapeutic areaCardiovascular
PhaseFDA-approved

Mechanism of action

Metolazone is a thiazide-like diuretic that blocks the Na-Cl cotransporter in the distal convoluted tubule, reducing blood volume and lowering blood pressure. It also has a mild direct vasodilatory effect on vascular smooth muscle. This dual action makes it effective for hypertension and edema management, particularly in patients with reduced renal function where other diuretics may be less effective.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Metolazone Tablets

What is Metolazone Tablets?

Metolazone Tablets is a Thiazide-like diuretic drug developed by NHS Greater Glasgow and Clyde, indicated for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.

How does Metolazone Tablets work?

Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.

What is Metolazone Tablets used for?

Metolazone Tablets is indicated for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.

Who makes Metolazone Tablets?

Metolazone Tablets is developed and marketed by NHS Greater Glasgow and Clyde (see full NHS Greater Glasgow and Clyde pipeline at /company/nhs-greater-glasgow-and-clyde).

Is Metolazone Tablets also known as anything else?

Metolazone Tablets is also known as metolazone.

What drug class is Metolazone Tablets in?

Metolazone Tablets belongs to the Thiazide-like diuretic class. See all Thiazide-like diuretic drugs at /class/thiazide-like-diuretic.

What development phase is Metolazone Tablets in?

Metolazone Tablets is FDA-approved (marketed).

What are the side effects of Metolazone Tablets?

Common side effects of Metolazone Tablets include Hypokalemia, Hyperuricemia, Hyperglycemia, Hyponatremia, Dizziness, Headache.

What does Metolazone Tablets target?

Metolazone Tablets targets Na-Cl cotransporter (NCC) and is a Thiazide-like diuretic.

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