Who are Metolazone Tablets's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lozol, Zaroxolyn, CHLORTHALIDONE, Combipres, Chlorthalidone with potassium chloride, Addition of oral Metolazone.

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Last reviewed 2026-05-17 · How we verify

Metolazone Tablets — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Metolazone Tablets (Metolazone Tablets) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

marketed Thiazide-like diuretic Na-Cl cotransporter (NCC) Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

Metolazone Tablets (Metolazone Tablets) — NHS Greater Glasgow and Clyde. Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Metolazone Tablets TARGET	Metolazone Tablets	NHS Greater Glasgow and Clyde	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
Chlorthalidone with potassium chloride	Chlorthalidone with potassium chloride	Brigham and Women's Hospital	marketed	Thiazide-like diuretic with potassium supplement	Sodium-chloride cotransporter (NCC)
Addition of oral Metolazone	Addition of oral Metolazone	University of North Carolina, Chapel Hill	marketed	Thiazide-like diuretic	Sodium-chloride cotransporter (NCC)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2028-03-26 — Combipres · 9066936 · US
2030-02-04 — Combipres · 9169238 · US
2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

Eurofarma Laboratorios S.A. · 1 drug in this class
Farma de Colombia SA · 1 drug in this class
Hospices Civils de Lyon · 1 drug in this class
NHS Greater Glasgow and Clyde · 1 drug in this class
University of North Carolina, Chapel Hill · 1 drug in this class
University of Virginia · 1 drug in this class
VA Office of Research and Development · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Metolazone Tablets — Competitive Intelligence Brief. https://druglandscape.com/ci/metolazone-tablets. Accessed 2026-05-17.

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