Last reviewed · How we verify
Combipres (Chlortalidone)
At a glance
| Generic name | Chlortalidone |
|---|---|
| Also known as | Hygroton, Thalitone, Thiazide diuretic |
| Sponsor | University Hospital Birmingham |
| Drug class | Thiazide-like Diuretic |
| Target | Carbonic anhydrase 7 |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
| First approval | 1960 |
Approved indications
- Edema
- Hypertensive disorder
- Peripheral Edema due to Chronic Heart Failure
- Pulmonary Edema due to Chronic Heart Failure
Common side effects
Drug interactions
- dofetilide
- lithium
Key clinical trials
- OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP) (NA)
- Effects of Antihypertensive Drug Treatment on Brain Blood Flow, Cognition, and Regulation of Nervous System in Older Adults With Hypertension. (EARLY_PHASE1)
- Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension (PHASE4)
- Hypertension in Young Adults Trial (PHASE2)
- Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension (PHASE4)
- Diuretics and Volume Overload in Early CKD (PHASE4)
- Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control (PHASE3)
- Efficacy and Safety of Olmesartan Associated With Chlorthalidone in Essential Arterial Hypertension Control (PHASE3)
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Combipres CI brief — competitive landscape report
- Combipres updates RSS · CI watch RSS
- University Hospital Birmingham portfolio CI