What are Thiazide-like Diuretic drugs?

Thiazide-like Diuretic drugs are pharmacologic agents that share a common mechanism (typically targeting Carbonic anhydrase 7). 5 are currently marketed, with 3 more in clinical development.

What are the marketed Thiazide-like Diuretic drugs?

Marketed Thiazide-like Diuretic drugs include Combipres, Indapamide (T2), Metolazone Oral Tablet, Addition of oral Metolazone, Metolazone Tablets.

Thiazide-like Diuretic

5 marketed 3 in Phase 3

This page covers all Thiazide-like Diuretic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Carbonic anhydrase 7, Sodium-chloride cotransporter (NCC), Na-Cl cotransporter (NCC).

Targets

Carbonic anhydrase 7 · Sodium-chloride cotransporter (NCC) · Na-Cl cotransporter (NCC)

Marketed (5)

Combipres · University Hospital Birmingham · Cardiovascular
Indapamide (T2) · Hospices Civils de Lyon · Cardiovascular
Indapamide is a thiazide-like diuretic that inhibits sodium reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.
Metolazone Oral Tablet · University of Virginia · Cardiovascular
Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.
Addition of oral Metolazone · University of North Carolina, Chapel Hill · Cardiovascular
Metolazone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting urinary excretion of water and electrolytes.
Metolazone Tablets · NHS Greater Glasgow and Clyde · Cardiovascular
Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.

Phase 3 pipeline (3)

GROUP C: Chlorthalidone · Farma de Colombia SA · Cardiovascular
Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, promoting urinary excretion and reducing blood volume and blood pressure.
Higroton® Laboratório Novartis · Eurofarma Laboratorios S.A. · Cardiovascular
Higroton (chlorthalidone) is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting urinary excretion and reducing blood volume and blood pressure.
Chlorthalidone (CTD) · VA Office of Research and Development · Cardiovascular
Chlorthalidone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the kidney, reducing blood volume and lowering blood pressure.