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Metolazone Oral Tablet
Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.
Metolazone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes to reduce blood volume and blood pressure. Used for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.
At a glance
| Generic name | Metolazone Oral Tablet |
|---|---|
| Also known as | Zaroxolyn |
| Sponsor | University of Virginia |
| Drug class | Thiazide-like diuretic |
| Target | Na-Cl cotransporter (NCC) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
As a thiazide-like diuretic, metolazone blocks the Na-Cl cotransporter in the kidney's distal tubule, reducing blood volume and sodium levels. This leads to decreased peripheral vascular resistance and lower blood pressure. It is particularly effective in patients with reduced renal function where other thiazides may be less effective.
Approved indications
- Hypertension
- Edema associated with congestive heart failure
- Edema associated with renal disease
Common side effects
- Hypokalemia
- Hyperuricemia
- Hyperglycemia
- Hyponatremia
- Dizziness
- Headache
Key clinical trials
- Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload (PHASE4)
- Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg (PHASE1)
- Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg (PHASE1)
- Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg (PHASE1)
- Role of Active Deresuscitation After Resuscitation: (PHASE2)
- DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance (PHASE3)
- Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing (PHASE4)
- Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metolazone Oral Tablet CI brief — competitive landscape report
- Metolazone Oral Tablet updates RSS · CI watch RSS
- University of Virginia portfolio CI