{"id":"metolazone-oral-tablet","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypokalemia"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hyponatremia"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a thiazide-like diuretic, metolazone blocks the Na-Cl cotransporter in the kidney's distal tubule, reducing blood volume and sodium levels. This leads to decreased peripheral vascular resistance and lower blood pressure. It is particularly effective in patients with reduced renal function where other thiazides may be less effective.","oneSentence":"Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:57.769Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Edema associated with congestive heart failure"},{"name":"Edema associated with renal disease"}]},"trialDetails":[{"nctId":"NCT06166654","phase":"PHASE4","title":"Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload","status":"RECRUITING","sponsor":"Johannes Grand","startDate":"2024-09-05","conditions":"Acute Heart Failure","enrollment":939},{"nctId":"NCT00649181","phase":"PHASE1","title":"Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2003-10","conditions":"Healthy","enrollment":52},{"nctId":"NCT00650195","phase":"PHASE1","title":"Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2004-02","conditions":"Healthy","enrollment":56},{"nctId":"NCT00649051","phase":"PHASE1","title":"Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2002-12","conditions":"Healthy","enrollment":52},{"nctId":"NCT06326112","phase":"PHASE2","title":"Role of Active Deresuscitation After Resuscitation:","status":"NOT_YET_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2024-05-01","conditions":"Fluid Overload, Critical Illness, Sepsis","enrollment":120},{"nctId":"NCT04860011","phase":"PHASE3","title":"DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance","status":"UNKNOWN","sponsor":"NHS Greater Glasgow and Clyde","startDate":"2021-04-27","conditions":"Heart Failure","enrollment":61},{"nctId":"NCT03746002","phase":"PHASE4","title":"Diuretic Effect of Metolazone Pre-dosing Versus Concurrent Dosing","status":"TERMINATED","sponsor":"University of Maryland, Baltimore","startDate":"2019-01-01","conditions":"Fluid Overload, Heart Failure Acute","enrollment":3},{"nctId":"NCT03574857","phase":"PHASE4","title":"Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance","status":"TERMINATED","sponsor":"University of Virginia","startDate":"2018-06-01","conditions":"Heart Failure, Heart Failure With Reduced Ejection Fraction, Heart Failure Acute","enrollment":5},{"nctId":"NCT02606253","phase":"PHASE4","title":"Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2016-02","conditions":"Heart Failure","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zaroxolyn"],"phase":"marketed","status":"active","brandName":"Metolazone Oral Tablet","genericName":"Metolazone Oral Tablet","companyName":"University of Virginia","companyId":"university-of-virginia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metolazone is a thiazide-like diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes to reduce blood volume and blood pressure. Used for Hypertension, Edema associated with congestive heart failure, Edema associated with renal disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}