Metolazone Oral Tablet — Competitive Intelligence Brief

Metolazone Oral Tablet (Metolazone Oral Tablet) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazide-like diuretic. Area: Cardiovascular.

marketed Thiazide-like diuretic Na-Cl cotransporter (NCC) Cardiovascular Small molecule

Target snapshot

Metolazone Oral Tablet (Metolazone Oral Tablet) — University of Virginia. Metolazone inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, promoting urinary excretion of water and electrolytes.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Metolazone Oral Tablet TARGET	Metolazone Oral Tablet	University of Virginia	marketed	Thiazide-like diuretic	Na-Cl cotransporter (NCC)
Lozol	INDAPAMIDE		marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1983-01-01
Zaroxolyn	METOLAZONE	I3 Pharms	marketed	Thiazide-like Diuretic [EPC]	Carbonic anhydrase 7	1973-01-01
Combipres	Chlortalidone	University Hospital Birmingham	marketed	Thiazide-like Diuretic	Carbonic anhydrase 7	1960-01-01
CHLORTHALIDONE	CHLORTHALIDONE		marketed	Thiazide-like Diuretic [EPC]	Na+/Cl− cotransporter	1960-01-01
Perindopril + Indapamide	Perindopril + Indapamide	Centre for Chronic Disease Control, India	marketed	ACE inhibitor + thiazide-like diuretic combination	Angiotensin-converting enzyme (ACE); sodium-chloride cotransporter
Amlodipine + Indapamide	Amlodipine + Indapamide	Centre for Chronic Disease Control, India	marketed	Calcium channel blocker + Thiazide-like diuretic combination	L-type voltage-gated calcium channels (amlodipine); sodium-chloride cotransporter (indapamide)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

• 2028-03-26 — Combipres · 9066936 · US
• 2030-02-04 — Combipres · 9169238 · US
• 2031-07-01 — Combipres · 9387249 · US

Sponsor landscape (Thiazide-like diuretic class)

1. Eurofarma Laboratorios S.A. · 1 drug in this class
2. Farma de Colombia SA · 1 drug in this class
3. Hospices Civils de Lyon · 1 drug in this class
4. NHS Greater Glasgow and Clyde · 1 drug in this class
5. University of North Carolina, Chapel Hill · 1 drug in this class
6. University of Virginia · 1 drug in this class
7. VA Office of Research and Development · 1 drug in this class