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Pruritus ani
Approved treatments
- phenylmercuric nitrate
Phenylmercuric nitrate works by releasing mercury ions that have antimicrobial and anti-inflammatory properties. - Flucorticin
- Aclovate
- Cordran · Aqua Pharms
- Cutivate · Teva Pharm
- Cortifoam · Pfizer
- Benzamycin · Mayne Pharma
- Topicort · Taro
- Derma-Smoothe/Fs · Eurofarma
- Cloderm · Legacy Pharma
- Cortone
- Ultravate · Ranbaxy
Ultravate works by binding to the glucocorticoid receptor, triggering a cascade of anti-inflammatory effects that reduce skin inflammation. - Diprolene · Merck & Co.
Diprolene works by binding to the glucocorticoid receptor in the skin, which reduces inflammation and suppresses the immune system. - Verdeso · Padagis Us
- Betamethasone Valerate · Fougera Pharms Inc
- Decadron · Generic (originally Merck)
- Flonase · GSK (GlaxoSmithKline)
- Sudafed PE · Generic (multiple manufacturers)
- Phenergan Vc W/ Codeine · ANI Pharmaceuticals
- Lignocaine · University of Malaya
- Lignospan Forte · Fresenius Kabi
Lidocaine stabilizes neuronal membrane by inhibiting ionic fluxes required for impulse initiation and conduction. - Nasonex · University of Alberta
- Medrol · Generic (originally Upjohn/Pfizer)
Potent synthetic glucocorticoid with 5x hydrocortisone potency and minimal mineralocorticoid activity, used for severe inflammatory conditions. - Betamethasone 17-Benzoate
- Cortef · Generic (originally Merck/Upjohn)
- Rodinolone
- Flixotide · Mundipharma Research Limited
- Fluticason · Creighton University
- Lidex
- Halog · Sun Pharma
- Lac-Hydrin · Sun Pharma
- Dermatop · Bausch Health
- Elocon · Merck & Co.
Elocon works by binding to the progesterone receptor, which reduces inflammation and immune response in the body. - Psorcon · Pfizer
- Cyclocort · Astellas Pharma
- Betametasone
Betamethasone works by binding to the glucocorticoid receptor, which then triggers a series of downstream effects that reduce inflammation and suppress the immune system. - Cortisol · University of Zurich
- Prelone · Generic (originally Schering)
- Benoxyl · Aier School of Ophthalmology, Central South University
- pramocaine
- Lidocain · Bayer
- prednisolon · Hannover Medical School
- Methylprednisolon · Leiden University Medical Center
- xylocain · Saint-Joseph University
- MOMETASONE
12.1 Mechanism of Action Mometasone furoate nasal spray is a corticosteroid demonstrating potent anti-inflammatory properties. The precise mechanism of corticosteroid action on allergic rhinitis is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation. In two clinical studies utilizing nasal antigen challenge, mometasone furoate nasal spray decreased some markers of the early- and late-phase allergic response. These observations included decreases (vs. placebo) in histamine and eosinophil cationic protein levels, and reductions (vs. baseline) in eosinophils, neutrophils, and epithelial cell adhesion proteins. The clinical significance of these findings is not known. The effect of mometasone furoate nasal spray on nasal mucosa following 12 months of treatment was examined in 46 patients with allergic rhinitis. There was no evidence of atrophy and there was a marked reduction in intraepithelial eosinophilia and inflammatory cell infiltration (e.g., eosinophils, lymphocytes, monocytes, neutrophils, and plasma cells).
Competitive intelligence
For the full treatment-landscape CI brief — marketed leaders side-by-side, pipeline by phase, recent regulatory actions, sponsor landscape:
- Pruritus ani patent landscape — cliff calendar, originator estates, attackable patents
- Pruritus ani treatment landscape brief
- Pruritus ani treatment updates RSS
Frequently asked questions about Pruritus ani
What drugs treat Pruritus ani?
Tracked treatments include phenylmercuric nitrate, Flucorticin, Aclovate, Cordran, Cutivate, Cortifoam, Benzamycin, Topicort.
What is the treatment for Pruritus ani?
Standard treatment for Pruritus ani includes phenylmercuric nitrate, Flucorticin, Aclovate, Cordran, Cutivate. See the treatment landscape page for first-line, second-line and salvage options.
Related
- Treatment landscape: Pruritus ani patent cliff · Pruritus ani CI report
- Treatment: phenylmercuric nitrate
- Treatment: Flucorticin
- Treatment: Aclovate
- Treatment: Cordran · Aqua Pharms
- Treatment: Cutivate · Teva Pharm
- All diseases: Browse the disease index · Disease landscape hub
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing