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Lignospan Forte (Lidocaine Hydrochloride)
Lidocaine stabilizes neuronal membrane by inhibiting ionic fluxes required for impulse initiation and conduction.
Lidocaine Hydrochloride (Lignospan Forte) is a topical amide-type local anesthetic indicated for anesthesia of irritated or inflamed mucous membranes of the mouth and pharynx. It stabilizes neuronal membranes by inhibiting ionic fluxes required for impulse initiation and conduction, with rapid hepatic metabolism and renal excretion. Contraindicated in patients with hypersensitivity to amide-type local anesthetics; concurrent use with methemoglobinemia-inducing drugs increases risk of this serious adverse effect. Modest hypotension may occur with excessive blood levels, but adverse effects are generally minimal when recommended dosages are not exceeded.
At a glance
| Generic name | Lidocaine Hydrochloride |
|---|---|
| Sponsor | Fresenius Kabi |
| Drug class | local anesthetic, amide type |
| Target | neuronal membrane ionic channels |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
| First approval | 1948 |
Mechanism of action
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure, attributable to a direct depressant effect on various cardiovascular system components. The net effect is normally a modest hypotension when recommended dosages are not exceeded.
Approved indications
- Hemorrhoids
- Infestation by Phthirus pubis
- Infestation by Sarcoptes scabiei var hominis
- Itching of skin
- Local Anesthesia for Endotracheal Intubation
- Local Anesthesia for Ophthalmologic Procedure
- Local Anesthesia for Urethral Pain
- Local anesthesia
- Local anesthetic intrathecal block
- Minor Skin Wound Pain
- Mouth Irritation
- Neuralgia
- Pediculosis capitis
- Postherpetic neuralgia
- Premature ejaculation
- Prevent Minor Bacterial Skin Infection
- Pruritus ani
- Regional Anesthesia for Ophthalmologic Surgery
- Skin irritation
- Suppression of the Gag Reflex
Boxed warnings
- For external use onlyAvoid contact with eyes and mucous memberanesDo not bandage tightly. Avoid contact with eyes and mucous memberanes. Do not bandage tightly.
Common side effects
- Back Pain
- Arthralgia
- Joint Swelling
- Muscle Spasm
- Osteoarthritis
- Abdominal Upper Pain
- Nasopharyngitis
- Ligament Sprain
- Puritus
- Alanine aminotransferase
- Diarrhoea
- Nausea
Drug interactions
- Nitrates/Nitrites (nitroglycerin, nitroprusside, nitric oxide, nitrous oxide)
- Local anesthetics (benzocaine, bupivacaine, mepivacaine, tetracaine, prilocaine, procaine, articaine, ropivacaine)
- Antineoplastic agents (cyclophosphamide, flutamide, rasburicase, ifosfamide, hydroxyurea)
- Antibiotics (dapsone, sulfonamides, nitrofurantoin, para-aminosalicylic acid)
- Antimalarials (chloroquine, primaquine)
- Anticonvulsants (phenytoin, sodium valproate, phenobarbital)
- Other drugs (acetaminophen, metoclopramide, sulfasalazine, quinine)
Patents
| Patent | Expiry | Type |
|---|---|---|
| 9370622 | 2035-09-28 | Method of Use |
| 8759401 | 2026-07-24 | Formulation |
| 9358338 | 2035-04-27 | Method of Use |
| 8540665 | 2029-10-22 | Method of Use |
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lignospan Forte CI brief — competitive landscape report
- Lignospan Forte updates RSS · CI watch RSS
- Fresenius Kabi portfolio CI