Last reviewed · How we verify
Methylprednisolon
At a glance
| Generic name | Methylprednisolon |
|---|---|
| Also known as | Depo-medrol, Glucocorticosteroid injection |
| Sponsor | Leiden University Medical Center |
| Target | Annexin A1, Short transient receptor potential channel 5, Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | FDA-approved |
Approved indications
- Acquired thrombocytopenia
- Acute lymphoid leukemia
- Adrenal cortical hypofunction
- Adrenogenital disorder
- Allergic rhinitis
- Angioedema
- Ankylosing spondylitis
- Articular gout
- Aspiration pneumonitis
- Asthma
- Atopic dermatitis
- Autoimmune disease
- Autoimmune hemolytic anemia
- Berylliosis
- Bursitis
- Cerebral edema
- Congenital adrenal hyperplasia
- Congenital hypoplastic anemia
- Contact dermatitis
- Crohn's disease
Common side effects
- Increased appetite
- Nausea
- Weight gain
- Moon face
- Fluid retention
- Hypertension
- Insomnia
- Mood swings
- Headache
- Acne
- Increased sweating
- Edema
Serious adverse events
- Anaphylaxis
- Cardiac arrest
- Circulatory collapse
- Myocardial rupture following recent myocardial infarction
- Peptic ulcer with possible perforation and hemorrhage
- Perforation of the small and large intestine
- Aseptic necrosis of femoral and humeral heads
- Convulsions
- Increased intracranial pressure with papilledema
- Arachnoiditis
Key clinical trials
- Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS (NA)
- Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma (PHASE3)
- A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001) (PHASE3)
- Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia (PHASE2)
- A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia (PHASE3)
- Loteprednol Etabonate Versus Prednisolone Acetate for Anterior Chamber Granulomas (PHASE4)
- Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction (PHASE2)
- Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB, Stage IIIB, IVA, or IVB Hodgkin Lymphoma (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Methylprednisolon CI brief — competitive landscape report
- Methylprednisolon updates RSS · CI watch RSS
- Leiden University Medical Center portfolio CI