Last reviewed · How we verify
xylocain
At a glance
| Generic name | xylocain |
|---|---|
| Also known as | Xylocain only |
| Sponsor | Saint-Joseph University |
| Target | 5-hydroxytryptamine receptor 3A, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, Sodium channel protein type 10 subunit alpha |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Approved indications
- Hemorrhoids
- Infestation by Phthirus pubis
- Infestation by Sarcoptes scabiei var hominis
- Itching of skin
- Local Anesthesia for Endotracheal Intubation
- Local Anesthesia for Ophthalmologic Procedure
- Local Anesthesia for Urethral Pain
- Local anesthesia
- Local anesthetic intrathecal block
- Minor Skin Wound Pain
- Mouth Irritation
- Neuralgia
- Pediculosis capitis
- Postherpetic neuralgia
- Premature ejaculation
- Prevent Minor Bacterial Skin Infection
- Pruritus ani
- Regional Anesthesia for Ophthalmologic Surgery
- Skin irritation
- Suppression of the Gag Reflex
Common side effects
- Hypotension
- Positional headaches
- Backache
- Shivering
- Drowsiness
- Dizziness
- Nervousness
- Apprehension
- Lightheadedness
- Confusion
- Euphoria
- Tinnitus
Serious adverse events
- Respiratory depression and arrest
- Convulsions
- Unconsciousness
- Bradycardia
- Cardiovascular collapse
- Cardiac arrest
- Anaphylactic reactions
- Total spinal block
- Loss of bladder and bowel control
- Permanent injury to extraocular muscles
Key clinical trials
- The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision (PHASE4)
- Comparison of the Effect of Combined Glenohumeral Joint and Subdeltoid Bursa Injection With Platelet-rich Plasma (PRP), Corticosteroid, and Normal Saline in Addition to Physical Therapy for Treatment of Frozen Shoulder (NA)
- Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management (NA)
- Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal Endoscopy (NA)
- Effect of Combined Ultrasound-guided Subdeltoid Corticosteroid Injections and Physiotherapy in Treatment of Patients With Chronic Subacromial Bursitis (NA)
- The Effect of Combined Hydrodilatation, Corticosteroid Injection, and Joint Mobilization for Treament of Frozen Shoulder (NA)
- TRICIN: Prospective Study on the Efficacy of Single Topical Trichloroacetic Acid (TCA) 85% in the Treatment of Cervical Intraepithelial Neoplasia (CIN 1/2) (NA)
- Ureteral Stent Versus Percutaneous Nephrostomy in Acutely Obstructed Infected Kidney (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- xylocain CI brief — competitive landscape report
- xylocain updates RSS · CI watch RSS
- Saint-Joseph University portfolio CI