Abbott Laboratories (ABT)

Quick facts

Marketed products

• Buffered pantoprazole · Gastroenterology
  Buffered pantoprazole inhibits gastric acid secretion by blocking the proton pump (H+/K+-ATPase) in parietal cells of the stomach.
• Calcijex · Other
• Calcium Gluceptate · Cardiovascular
• cefdinir (Omnicef) · Infectious Disease
  Cefdinir is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.
• Prosom · Neuroscience
• Hectorol® injection
• Lopinavir/ritonavir (Kaletra) · Infectious Disease
  Lopinavir and ritonavir are protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
• Lotrel (amlodipine/benazepril) · Cardiovascular
  Lotrel combines a calcium channel blocker and an ACE inhibitor to lower blood pressure through two complementary pathways: relaxing blood vessel smooth muscle and reducing angiotensin II-mediated vasoconstriction.
• Metofane · Metabolic
  Metofane works by binding to the GABA-A receptor and anion channel, enhancing the inhibitory effects of GABA to produce sedation and analgesia.
• paricalcitol capsule · Nephrology / Endocrinology
  Paricalcitol is a selective vitamin D receptor agonist that activates the vitamin D receptor to regulate calcium and phosphorus metabolism and suppress parathyroid hormone secretion.
• paricalcitol capsules · Nephrology / Endocrinology
  Paricalcitol is a selective vitamin D receptor agonist that activates the vitamin D receptor to regulate calcium and phosphate metabolism and suppress parathyroid hormone secretion.
• raltegravir (RAL) · Infectious Disease
  Raltegravir inhibits HIV integrase, preventing the virus from integrating its genetic material into the host cell's DNA.
• Sevoflurane Inhalational Induction and Maintenance · Anesthesiology
  Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
• sibutramine hydochloride monohydrate · Obesity / Weight Management
  Sibutramine is a norepinephrine-serotonin reuptake inhibitor that increases satiety and reduces appetite by blocking the reuptake of these neurotransmitters in the central nervous system.
• Golytely · Gastroenterology
  Golytely works by neutralizing stomach acid and helping to protect the stomach lining.
• Pentothal · Neuroscience
• trandolapril/verapamil · Cardiovascular
  Trandolapril inhibits angiotensin-converting enzyme (ACE) to reduce blood pressure, while verapamil blocks calcium channels to slow heart rate and further lower blood pressure.
• Venocur Triplex®

Phase 3 pipeline

• ABT-335 and atorvastatin calcium · Cardiovascular
  ABT-335 is a fibrate that reduces triglycerides and raises HDL cholesterol, combined with atorvastatin calcium which inhibits HMG-CoA reductase to lower LDL cholesterol.
• ABT-335 and simvastatin · Cardiovascular
  ABT-335 (fenofibrate) combined with simvastatin works by reducing triglycerides and LDL cholesterol through dual lipid-lowering pathways.
• adalimumab (D2E7) · Immunology
  Adalimumab is a fully human monoclonal antibody that selectively binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors.
• Ademetionine IV+tablet · Hepatology / Gastroenterology
  Ademetionine is a methyl donor that replenishes cellular methylation capacity and supports hepatic function and neurotransmitter synthesis.
• Ademetionine tablet · Hepatology / Gastroenterology
  Ademetionine is a methyl donor that replenishes cellular S-adenosylmethionine (SAM) levels to support methylation reactions and hepatic function.
• aspirin placebo (ASA Pbo) · Cardiovascular
  Aspirin works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins and thromboxanes.
• clarithromycin immediate-release tablets · Infectious diseases
  Clarithromycin is a macrolide antibiotic that inhibits protein synthesis by binding to the 50S ribosomal subunit.
• Creon® 10000 · Gastroenterology
  Creon 10000 is a pancreatic enzyme replacement therapy that supplies lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency.
• Creon N · Gastroenterology
  Creon N is a pancreatic enzyme replacement therapy that provides lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency.
• Double-blind adalimumab · Immunology
  Adalimumab is a monoclonal antibody that binds to and neutralizes tumor necrosis factor-alpha (TNF-α), reducing inflammatory signaling.
• Double-Blind Adalimumab/Placebo + MTX · Immunology
  Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha signaling to reduce inflammation, combined with methotrexate for enhanced immunosuppressive effect.
• felodipine/ramipril · Cardiovascular
  Felodipine is a calcium channel blocker that relaxes blood vessels, while ramipril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure.
• hydrocodone / acetaminophen extended release · Pain management
  Hydrocodone is an opioid agonist that binds to opioid receptors in the brain, while acetaminophen is a non-opioid analgesic that works by inhibiting the production of prostaglandins.
• Hydrocodone/Acetaminophen on Extended Release · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.
• Leuprolide acetate - Formulation A · Oncology; Endocrinology
  Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
• Leuprolide acetate - Formulation B · Oncology; Endocrinology
  Leuprolide acetate is a gonadotropin-releasing hormone (GnRH) agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased sex hormone production.
• Lupron (leuprolide acetate) · Oncology
  Leuprolide is a GnRH agonist that suppresses luteinizing hormone and follicle-stimulating hormone, leading to decreased testosterone and estrogen production.
• Mebeverine+Simethicone · Gastroenterology
  Mebeverine relaxes smooth muscle in the gastrointestinal tract while simethicone reduces gas bloating by breaking down gas bubbles.
• metoprolol/HCT · Cardiovascular
  Metoprolol/HCT is a beta-blocker that works by blocking the effects of the hormone epinephrine, and also has a diuretic effect to reduce blood pressure.
• Mitizax · Other
• Niacin ER/Simvastatin Tablets · Cardiovascular
  Niacin ER/Simvastatin combines extended-release niacin (which increases HDL and lowers triglycerides) with simvastatin (a statin that inhibits HMG-CoA reductase to lower LDL cholesterol).
• niacin extended-release (NER)
• OLE BSA Adalimumab +/- MTX · Immunology
  Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha signaling to reduce inflammation, with optional methotrexate co-administration to enhance efficacy.
• OLE FD Adalimumab +/- MTX · Immunology
  Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha signaling to reduce inflammation, with optional methotrexate co-administration to enhance efficacy.
• Open-labelAdalimumabRescue · Immunology
  Adalimumab is a TNF-alpha inhibitor that blocks tumor necrosis factor-alpha to reduce inflammation and immune-mediated disease activity.
• placebo adalimumab, placebo MTX · Immunology
  Adalimumab is a monoclonal antibody that binds to tumor necrosis factor-alpha (TNF-alpha), preventing its interaction with cell surface TNF receptors and thereby reducing inflammation.
• Placebo Eprosartan mesylate · Cardiovascular
  Eprosartan mesylate is an angiotensin II receptor antagonist that blocks the action of angiotensin II, a potent vasoconstrictor, to lower blood pressure.
• Racecadotril plus ORS · Gastroenterology
  Racecadotril inhibits enkephalinase to reduce intestinal fluid secretion, while ORS provides oral rehydration therapy to replace lost electrolytes and fluids.
• SA-001 · Diabetes
  SA-001 is a small molecule that targets the SGLT2 receptor.
• Testosterone (T) Gel 1.62% · Endocrinology
  Testosterone gel delivers exogenous testosterone through transdermal absorption to replace deficient endogenous testosterone in hypogonadal men.
• verapamil/trandolapril

Phase 2 pipeline

• Creon IR · Gastroenterology
  Pancreatic enzyme replacement

Phase 1 pipeline

• ABT-614
• ABT-SLV361
• Cortiment · Other
• Cytochrome P450 inhibitor
• Fat Emulsion 2%
• Fat Emulsion 20%
• PDL192
• PG110
• SLV354

Competitive intelligence

For the full portfolio CI brief — phase mix, recent regulatory actions, upcoming PDUFA dates, patent timeline, class-overlap with competitors:

• Abbott Laboratories portfolio CI brief
• Abbott Laboratories pipeline updates RSS