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Pentothal (THIOPENTAL)
Pentothal (generic name: THIOPENTAL) is a thiopental Small molecule drug developed by Abbott. It is currently FDA-approved (first approved 1982) for Benign intracranial hypertension, Epilepsy, General anesthesia.
Pentothal, also known as thiopental, is a small molecule used in total intravenous anesthesia (TIVA) and inhalation anesthesia. It has been studied in various clinical trials for conditions such as pituitary tumor, cardiac arrest, and status epilepticus.
At a glance
| Generic name | THIOPENTAL |
|---|---|
| Sponsor | Abbott |
| Drug class | thiopental |
| Target | GABA-A receptor alpha-1/beta-2/gamma-2 |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
| First approval | 1982 |
Approved indications
- Benign intracranial hypertension
- Epilepsy
- General anesthesia
- Narcoanalysis
Common side effects
Key clinical trials
- Total Arch Replacement With Frozen Elephant Trunk Versus Hemiarch Replacement in the Management of Acute Type A Aortic Dissection (NA)
- Optic Nerve Sheath Diameter and Postoperative Cognitive Disfunction at Laparoscopic Surgery
- Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury (NA)
- Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Pediatric Frontal and Nasal Bispectral Index (NA)
- The Effects of Propofol and Thiopental on Nitric Oxide Production and Release in Erythrocytes (NA)
- Assessment of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) for Maternal Pre-oxygenation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Pentothal CI brief — competitive landscape report
- Pentothal updates RSS · CI watch RSS
- Abbott portfolio CI
Frequently asked questions about Pentothal
What is Pentothal?
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When was Pentothal approved?
What development phase is Pentothal in?
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Related
- Drug class: All thiopental drugs
- Target: All drugs targeting GABA-A receptor alpha-1/beta-2/gamma-2
- Manufacturer: Abbott — full pipeline
- Therapeutic area: All drugs in Neuroscience
- Indication: Drugs for Benign intracranial hypertension
- Indication: Drugs for Epilepsy
- Indication: Drugs for General anesthesia
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing