Last reviewed · How we verify
Epilepsy
Approved treatments
- Valium · Generic (originally Roche)
- Epilim · Sanofi
- Phenytoin Sodium · Viatris
Phenytoin Sodium works by stabilizing the threshold against hyperexcitability caused by excessive stimulation. - Tegretol · Novartis AG (originally Geigy)
Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation, potentially alleviating seizures and pain. - Lamictal · GSK
- Didione
Didione works by modulating the activity of neurons in the brain to control seizures. - Gabob
Gabob is thought to work by modulating the activity of certain neurotransmitters in the brain. - Metylfenemal
- Crampol
Crampol works by modulating neuronal activity to reduce seizure frequency. - Neocitrullamon
Neocitrullamon is thought to work by stabilizing neuronal membranes and reducing excitability. - Metabarbital · AbbVie
- Carbamazepin · Enanta Pharmaceuticals, Inc
- Depakene · Generic (originally Abbott/AbbVie)
Broad-spectrum anticonvulsant that enhances GABA activity, blocks sodium and calcium channels, and inhibits histone deacetylase. - phenobarbitone · Institute of Child Health
- Cerebyx · Pfizer
Cerebyx works by stabilizing the inactivated state of sodium channels, preventing the rapid firing of neurons that can lead to seizures. - Mesantoin · Novartis
- Mysoline · Bausch Health
- Succitimal
- Amobarbitone
- Nembutal Sodium · Oak Pharms
- Paradione
- Pentothal · Abbott
- Felbatol · Mylan Speciality Lp
Felbamate's exact mechanism is unknown, but it shows anticonvulsant activity in various animal models and interacts with the NMDA receptor-ionophore complex. - AM(FDC) · Medecins Sans Frontieres, Netherlands
- Dilantin · Pfizer
Phenytoin exerts its therapeutic effect by voltage-dependent blockade of membrane sodium channels. - Celontin · Pfizer
Celontin works by blocking the activity of voltage-gated T-type calcium channels in the brain. - mesuximide · Assistance Publique - Hôpitaux de Paris
- Divalproex · University of Chicago
- AM(LT) · Medecins Sans Frontieres, Netherlands
am(lt) is a small molecule that works by interacting with a specific target in the body, but its exact mechanism is unknown. - Phenurone · Abbvie
Clinical guidelines
- FDA label — adj
Oral diazepam tablets may be used adjunctively in convulsive disorders, although it has not proved useful as the sole therapy. - FDA label — 1L|adj
Valproic acid oral solution is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. - FDA label — 1L|adj
Valproic acid oral solution is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures.