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Mysoline (PRIMIDONE)
Mysoline (Primidone) is an anti-epileptic agent developed by Valeant, targeting the transient receptor potential cation channel subfamily M member 3. It is a small molecule modality approved by the FDA in 1954 for various seizure disorders, including epilepsy and bipolar disorder in remission. Mysoline is available as a generic medication, with multiple manufacturers, and is off-patent. As an anti-epileptic agent, Mysoline is used to control seizures and prevent their recurrence. It is essential to monitor patients for potential side effects and interactions.
At a glance
| Generic name | PRIMIDONE |
|---|---|
| Sponsor | Bausch Health |
| Drug class | Anti-epileptic Agent [EPC] |
| Target | Transient receptor potential cation channel subfamily M member 3 |
| Modality | Small molecule |
| Therapeutic area | Metabolic |
| Phase | FDA-approved |
| First approval | 1954 |
Approved indications
- Bipolar disorder in remission
- Epilepsy
- Epilepsy characterized by intractable complex partial seizures
- Lennox-Gastaut syndrome
- Localization-related epilepsy
- Simple partial seizure
- Tonic-clonic epilepsy
- Tonic-clonic seizure
Common side effects
- ataxia
- vertigo
- nausea
- anorexia
- vomiting
- fatigue
- hyperirritability
- emotional disturbances
- sexual impotency
- diplopia
- nystagmus
- drowsiness
Drug interactions
- CYP1A2 Substrates
- CYP2B6 Substrates
- CYP2C8 Substrates
- CYP2C9 Substrates
- CYP3A4 Substrates
- P-glycoprotein Substrates
- aripiprazole
- ciclosporin
- metronidazole
- quetiapine
- sodium oxybate
- warfarin
Key clinical trials
- Population Pharmacokinetics of Antiepileptic in Pediatrics
- Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor
- Safety and Effectiveness of Unilateral MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor
- Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor
- Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma (PHASE1,PHASE2)
- Effect of Primidone on Platelet Responsiveness in Patients Determined to be Clopidogrel Resistant (PHASE2)
- Celecoxib in Patients With Newly Diagnosed GBM Who Are Receiving Anticonvulsant Drugs and Undergoing RT (PHASE2)
- Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |