Last reviewed · How we verify
Divalproex
At a glance
| Generic name | Divalproex |
|---|---|
| Also known as | Depakote, Depakote ER, Valproic Acid, Divalproex (Depakote) |
| Sponsor | University of Chicago |
| Target | Alcohol dehydrogenase [NADP(+)], Histone deacetylase 1, Histone deacetylase 2 |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
Approved indications
- Absence seizure
- Bipolar affective disorder, current episode manic
- Epilepsy
- Epilepsy characterized by intractable complex partial seizures
- Migraine Prevention
Common side effects
- Vomiting
- Nausea
- Somnolence
- Dizziness
- Insomnia
- Tremor
- Headache
- Alopecia
- Weight gain
- Ataxia
- Confusion
- Depression
Serious adverse events
- Hepatotoxicity
- Pancreatitis
- Thrombocytopenia
- Tardive dyskinesia
- Catatonic reaction
- Discoid lupus erythematosus
- Hypertension
- Hypotension
- Fecal incontinence
- Urinary incontinence
Key clinical trials
- Evaluation of Intravenous Sodium Valproate on Interleukin-6 Levels in Patients With TMJ Disc Displacement (PHASE2)
- A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) (PHASE3)
- Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma (PHASE2)
- A Study of the Effectiveness of Risk Minimization Measures Related to Depakine® (Sodium Valproate) in Saudi Arabia
- A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants (PHASE1)
- A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine (PHASE3)
- Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates (PHASE1)
- The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. (PHASE1)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |