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Sevoflurane Inhalational Induction and Maintenance
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling.
Sevoflurane is a volatile anesthetic that depresses the central nervous system by enhancing inhibitory GABA neurotransmission and inhibiting excitatory glutamate signaling. Used for Induction and maintenance of general anesthesia in adult and pediatric patients undergoing surgery.
At a glance
| Generic name | Sevoflurane Inhalational Induction and Maintenance |
|---|---|
| Also known as | ABT-941, sevoflurane, Ultane, Sevorane, Sevofrane |
| Sponsor | Abbott |
| Drug class | Volatile anesthetic agent |
| Target | GABA receptors, NMDA receptors, potassium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a halogenated ether that acts as a general anesthetic by modulating multiple ion channels and neurotransmitter receptors in the brain, primarily potentiating GABAergic inhibition while suppressing glutamatergic excitation. The exact molecular mechanism remains incompletely understood, but the net effect is rapid loss of consciousness and maintenance of anesthesia suitable for induction and ongoing anesthetic maintenance during surgery.
Approved indications
- Induction and maintenance of general anesthesia in adult and pediatric patients undergoing surgery
Common side effects
- Emergence delirium
- Postoperative nausea and vomiting
- Airway irritation
- Hypotension
- Bradycardia
- Hepatotoxicity (rare)
Key clinical trials
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Relationship Between Preoperative Anxiety, Postoperative Pain, and Emergence Delirium in Pediatric Surgery
- Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients
- SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke (PHASE4)
- Impact of Anesthesia Maintenance Methods on 5-year Survival After Surgery (NA)
- Minimal Flow Anesthesia and Infection Risk (NA)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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