Last reviewed 2026-04-23 · How we verify

Creon N

Creon N is a pancreatic enzyme replacement therapy that provides lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency.

Creon N is a pancreatic enzyme replacement therapy that provides lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency. Used for Exocrine pancreatic insufficiency, Cystic fibrosis, Chronic pancreatitis.

At a glance

Mechanism of action

Creon N contains enteric-coated pancreatic enzymes derived from porcine pancreas. These enzymes are released in the small intestine to supplement deficient endogenous pancreatic secretions, improving nutrient absorption and reducing malabsorption symptoms in patients with exocrine pancreatic insufficiency.

Approved indications

• Exocrine pancreatic insufficiency
• Cystic fibrosis
• Chronic pancreatitis
• Post-pancreatic surgery

Common side effects

• Abdominal pain
• Diarrhea
• Constipation
• Nausea
• Fibrosing colonopathy (rare, high-dose)

Key clinical trials

• A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis (PHASE3)

Primary sources

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