Last reviewed 2026-04-23 · How we verify

Creon® 10000

Creon 10000 is a pancreatic enzyme replacement therapy that supplies lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency.

Creon 10000 is a pancreatic enzyme replacement therapy that supplies lipase, protease, and amylase to aid digestion of fats, proteins, and carbohydrates in patients with pancreatic insufficiency. Used for Exocrine pancreatic insufficiency due to cystic fibrosis, Exocrine pancreatic insufficiency due to chronic pancreatitis, Exocrine pancreatic insufficiency due to pancreatic surgery.

At a glance

Mechanism of action

Creon contains enteric-coated pancreatic enzymes (lipase, protease, and amylase) that are released in the small intestine to replace deficient endogenous pancreatic enzymes. This restores the digestive capacity in patients with exocrine pancreatic insufficiency, allowing proper nutrient absorption and reducing malabsorption symptoms. The enteric coating protects the enzymes from gastric acid degradation, ensuring they reach the small intestine intact.

Approved indications

• Exocrine pancreatic insufficiency due to cystic fibrosis
• Exocrine pancreatic insufficiency due to chronic pancreatitis
• Exocrine pancreatic insufficiency due to pancreatic surgery

Common side effects

• Abdominal pain
• Nausea
• Diarrhea
• Constipation
• Fibrosing colonopathy (rare, high-dose)

Key clinical trials

• Equivalence Study to Compare Two Strengths of Creon in China (PHASE3)
• A Double-blind, Randomized, Multicenter, Cross-over Study to Compare the Effect of Creon N and Creon® on Fat Digestion in Subjects ≥ 12 Years of Age With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis (PHASE3)

Primary sources

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