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Metofane (METHOXYFLURANE)
Metofane works by binding to the GABA-A receptor and anion channel, enhancing the inhibitory effects of GABA to produce sedation and analgesia.
Metofane (methoxyflurane) is a small molecule drug that targets the GABA-A receptor and anion channel. It is owned by Abbott, but its commercial status, including patent status and generic availability, is unknown. The exact indications, half-life, and bioavailability of Metofane are also unclear. As a result, its clinical use and safety profile are not well established. Further research is needed to determine the potential benefits and risks of this medication.
At a glance
| Generic name | METHOXYFLURANE |
|---|---|
| Sponsor | Abbott |
| Drug class | methoxyflurane |
| Target | Glycine receptor subunit alpha-1, GABA-A receptor; anion channel |
| Modality | Small molecule |
| Therapeutic area | Metabolic |
| Phase | FDA-approved |
Mechanism of action
Imagine your brain is like a busy city with lots of noise and activity. GABA is like a traffic cop that helps calm things down. Metofane helps the traffic cop work better, so the city becomes quieter and less painful.
Approved indications
Common side effects
Key clinical trials
- Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction (PHASE3)
- 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion (PHASE4)
- METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation (HYPNOLUX) (PHASE4)
- Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study (PHASE2)
- Methoxyflurane for IUD Insertion and Endometrial Biopsy (NA)
- Trial to Assess the Efficacy and Safety During Convective Radiofrequency Water Vapor Thermal Therapy (REZUM) for Benign Prostate Hyperplasia (PHASE3)
- Penthrox in Otolaryngology
- Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial (PHASE1,PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Metofane CI brief — competitive landscape report
- Metofane updates RSS · CI watch RSS
- Abbott portfolio CI