What are Loop diuretic drugs?

Loop diuretic drugs are pharmacologic agents that share a common mechanism (typically targeting Na-K-2Cl cotransporter (NKCC2)). 15 are currently marketed, with 10 more in clinical development.

What are the marketed Loop diuretic drugs?

Marketed Loop diuretic drugs include Low-dose furosemide, Furosemide (Diuretic), Lasix ONYU, IV loop diuretic, torasemide-PR, Immedate Release Torsemide Tablets.

Loop diuretic

15 marketed 6 in Phase 3 4 in Phase 2

This page covers all Loop diuretic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Na-K-2Cl cotransporter (NKCC2), Na-K-2Cl cotransporter 2, Na-K-2Cl cotransporter 2 (NKCC2).

Targets

Na-K-2Cl cotransporter (NKCC2) · Na-K-2Cl cotransporter 2 · Na-K-2Cl cotransporter 2 (NKCC2) · Sodium-potassium-chloride cotransporter · NKCC2

Marketed (15)

Low-dose furosemide · Larissa University Hospital · Cardiovascular
Low-dose furosemide inhibits the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium reabsorption and promoting diuresis.
Furosemide (Diuretic) · Jose J Zaragoza, MD MSc · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
Lasix ONYU · University of Florida · Cardiovascular
Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
IV loop diuretic · NxStage Medical · Cardiovascular
IV loop diuretics inhibit the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, reducing sodium and water reabsorption to increase urine output.
torasemide-PR · Ferrer Internacional S.A. · Cardiovascular
Torasemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
Immedate Release Torsemide Tablets · Sarfez Pharmaceuticals, Inc. · Cardiovascular
Torsemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
furosemide administration · Unity Health Toronto · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the loop of Henle, promoting diuresis and reducing fluid volume.
Torasemide (Diuver) · Society of Specialists in Heart Failure · Cardiovascular
Torasemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting fluid and electrolyte excretion.
Torsemide Tablets · China National Center for Cardiovascular Diseases · Cardiovascular
Torsemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
loop diuretic · The Christ Hospital · Cardiovascular
Loop diuretics inhibit the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium and chloride and increasing urine output.
placebo+torasemide · Shanghai Chest Hospital · Cardiovascular
Torasemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary fluid and electrolyte excretion.
Lasix 25 · Heart Care Foundation · Cardiovascular
Lasix (furosemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting urinary excretion of water and electrolytes.
Furosemide dose escalation · University of North Carolina, Chapel Hill · Cardiovascular
Furosemide is a loop diuretic that inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle, promoting increased urine output and fluid elimination.
IV Loop Diuretics · Nuwellis, Inc. · Cardiovascular
IV loop diuretics inhibit the sodium-potassium-chloride co-transporter in the thick ascending limb of the loop of Henle, increasing urinary sodium and water excretion.
Furosemide intravenous solution · Lakeland Regional Health Systems, Inc. · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle, promoting diuresis and reducing fluid volume.

Phase 3 pipeline (6)

Diuretics : Furosemide · Assistance Publique - Hôpitaux de Paris · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting rapid urinary excretion of water and electrolytes.
furosemide and hypertonic saline solution · Aspirus Heart and Vascular Institute-Research and Education · Cardiovascular
Furosemide is a loop diuretic that works by inhibiting the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle, leading to increased urine production and decreased fluid volume.
Furosemide intravenous infusion · Wroclaw Medical University · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the thick ascending limb of the loop of Henle, promoting diuresis and reducing fluid overload.
Loop Diuretics · Policlinico Casilino ASL RMB · Cardiovascular
Loop diuretics inhibit the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing sodium and chloride reabsorption and increasing urine output.
Furosemide 20 Milligrams · Instituto de Investigación Sanitaria Aragón · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle, promoting diuresis and reducing fluid volume.
Furosemide oral tablets · Sankyo Pharma Gmbh · Cardiovascular
Furosemide inhibits sodium and chloride reabsorption in the loop of Henle, promoting diuresis and reducing fluid overload.

Phase 2 pipeline (4)

Immediate release torsemide · Sarfez Pharmaceuticals, Inc. · Cardiovascular
Inhibits the sodium-chloride cotransporter in the distal convoluted tubule of the kidneys.
Furosemide Topical Gel · Maruho Co., Ltd. · Cardiovascular
Furosemide acts as a loop diuretic by inhibiting the sodium-potassium-chloride cotransporter in the ascending limb of the loop of Henle.
Extended release torsemide · Sarfez Pharmaceuticals, Inc. · Cardiovascular
Torsemide is a loop diuretic that works by inhibiting the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle in the kidneys.
Bumetanide white, oblong, scored tablet · B&A Therapeutics · Cardiovascular
Inhibits the Na-K-2Cl cotransporter 2 (NKCC2) in the thick ascending limb of the loop of Henle.