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Furosemide intravenous solution
Furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle, promoting diuresis and reducing fluid volume.
Furosemide inhibits sodium and chloride reabsorption in the ascending loop of Henle, promoting diuresis and reducing fluid volume. Used for Edema associated with congestive heart failure, Edema associated with hepatic cirrhosis, Edema associated with renal disease.
At a glance
| Generic name | Furosemide intravenous solution |
|---|---|
| Also known as | Lasix |
| Sponsor | Lakeland Regional Health Systems, Inc. |
| Drug class | Loop diuretic |
| Target | Na-K-2Cl cotransporter (NKCC2) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Furosemide is a loop diuretic that blocks the Na-K-2Cl cotransporter in the thick ascending limb of the loop of Henle, preventing reabsorption of sodium, potassium, and chloride. This increases urine output and reduces total body fluid volume, thereby decreasing preload on the heart and lowering blood pressure. The intravenous formulation provides rapid onset of action, making it useful in acute settings.
Approved indications
- Edema associated with congestive heart failure
- Edema associated with hepatic cirrhosis
- Edema associated with renal disease
- Hypertension
- Acute pulmonary edema
Common side effects
- Hypokalemia
- Hyperuricemia
- Ototoxicity (with high doses)
- Dehydration
- Hypotension
- Hyperglycemia
- Hyponatremia
Key clinical trials
- Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure (PHASE4)
- Effect of Giving Reduced Fluid in Children After Trauma (NA)
- PuO2 in RenalGuard Pilot Study (NA)
- Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure (PHASE3)
- SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF (PHASE4)
- Furosemide Use to Fill the Bladder of Pediatric Females Awaiting Pelvic Ultrasound (EARLY_PHASE1)
- Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial (PHASE3)
- Hypertonic Saline Therapy in Ambulatory Heart Failure Unit. (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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