Live attenuated vaccine

This page covers all Live attenuated vaccine drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Mumps virus surface antigens, Poliovirus type 2, Varicella-zoster virus (VZV).

Targets

Mumps virus surface antigens · Poliovirus type 2 · Varicella-zoster virus (VZV) · Measles virus surface glycoproteins (H and F proteins) · Hepatitis A virus · Rotavirus VP4 and VP7 surface proteins · Vaccinia virus antigens (envelope and intracellular proteins) · Varicella-zoster virus · Poliovirus serotypes 1 and 3 · Poliovirus type 1

Marketed (55)

• Bacille Calmette Guerin (BCG) · Bandim Health Project · Immunology, Oncology, Infectious Disease
  BCG is a live attenuated mycobacterial vaccine that stimulates innate and adaptive immune responses to enhance anti-tumor and anti-infectious immunity.
• Rotavirus vaccine · PATH · Immunology / Infectious Disease
  Rotavirus vaccine stimulates the immune system to produce antibodies and cellular immunity against rotavirus, preventing infection and severe gastroenteritis.
• Mumps vaccine · Sinovac (Dalian) Vaccine Technology Co., Ltd. · Immunology / Infectious Disease
  The mumps vaccine stimulates the immune system to produce antibodies and cellular immunity against the mumps virus, preventing infection and disease.
• BCG solvent · Bandim Health Project · Immunology; Infectious Disease
  BCG (Bacillus Calmette-Guérin) is a live attenuated mycobacterial vaccine that stimulates innate and adaptive immune responses to enhance immunological protection.
• Herpes Zoster Vaccine, Live · Changchun BCHT Biotechnology Co. · Immunology / Infectious Disease
  This live attenuated vaccine stimulates the immune system to recognize and respond to varicella-zoster virus, preventing herpes zoster (shingles) reactivation.
• live attenuated Japanese encephalitis vaccine · Chinese Academy of Medical Sciences · Immunology
  This live attenuated vaccine stimulates immune responses against Japanese encephalitis virus by introducing a weakened form of the virus that replicates but does not cause disease.
• MMR vaccine · Sri Edupuganti, MD MPH · Immunology / Infectious Disease
  The MMR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses by introducing live attenuated (weakened) forms of these pathogens.
• mOPV2 at 6 and 8 weeks of age · Centers for Disease Control and Prevention · Immunology / Infectious Disease
  mOPV2 is a live attenuated oral polio vaccine that stimulates immune responses against poliovirus type 2 to prevent poliomyelitis infection.
• mOPV2 at 6 and 7 weeks of age · Centers for Disease Control and Prevention · Immunology / Infectious Disease
  mOPV2 is a live attenuated oral polio vaccine that stimulates immune responses against poliovirus type 2 to prevent poliomyelitis infection.
• Varicella Vaccine · Novartis · Immunology / Infectious Disease
  Varicella vaccine stimulates the immune system to produce antibodies and cellular immunity against the varicella-zoster virus, preventing chickenpox infection.
• yellow fever vaccine (YFV) · PATH · Immunology / Infectious Disease
  Yellow fever vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus through a live attenuated viral strain.
• Herpes Zoster · Canadian Immunization Research Network · Immunology / Infectious Disease
  Herpes Zoster vaccine stimulates the immune system to prevent infection and reactivation of varicella-zoster virus.
• Yellow Fever · Sanofi Pasteur, a Sanofi Company · Immunology / Infectious Disease
  The yellow fever vaccine stimulates the immune system to produce antibodies and cellular immunity against the yellow fever virus through a live attenuated viral strain.
• Live attenuated HAV vaccine · Sinovac Biotech Co., Ltd · Immunology
  This vaccine contains live attenuated (weakened) hepatitis A virus that stimulates the immune system to produce antibodies and cellular immunity against hepatitis A without causing disease.
• Measles, mumps, rubella vaccine · PATH · Immunology / Infectious Disease
  The MMR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses by exposing it to attenuated (weakened) forms of these pathogens.
• Measles Vaccine (MV) · PATH · Immunology / Infectious Disease
  The measles vaccine stimulates the immune system to produce antibodies and cellular immunity against the measles virus, preventing infection and disease.
• MMR vaccination · Klara M. Pósfay Barbe · Immunology / Infectious Disease
  MMR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses through live attenuated viral antigens.
• Live attenuated influenza vaccine · The University of Hong Kong · Immunology
  This vaccine contains live but weakened influenza viruses that replicate in the nasal mucosa to stimulate both mucosal and systemic immune responses without causing disease.
• Measles, Mumps, Rubella vaccination · N.M. Wulffraat · Immunology / Infectious Disease
  The MMR vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses through live attenuated viral antigens.
• Measles vaccine · Bandim Health Project · Immunology / Infectious Disease
  The measles vaccine stimulates the immune system to produce antibodies and cellular immunity against the measles virus, preventing infection and disease.
• Attenuated Hepatitis A Vaccine, H2 Strain · Jiangsu Province Centers for Disease Control and Prevention · Immunology
  The Attenuated Hepatitis A Vaccine, H2 Strain, works by introducing a live, weakened form of the hepatitis A virus to stimulate an immune response.
• Zoster Vaccine Live · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  This live attenuated varicella-zoster virus vaccine stimulates the immune system to recognize and prevent herpes zoster (shingles) by boosting cell-mediated immunity against VZV.
• Vivotif Typhoid Oral Vaccine · University of Maryland, Baltimore · Immunology / Infectious Disease
  Vivotif is a live attenuated oral typhoid vaccine that stimulates immune responses against Salmonella typhi through mucosal and systemic immunity.
• Rotavirus Vaccine, Live, Pentavalent · Sanofi Pasteur, a Sanofi Company · Immunology / Infectious Disease
  A live attenuated pentavalent rotavirus vaccine that stimulates immune responses against the five most common rotavirus serotypes to prevent rotavirus gastroenteritis.
• Norwalk Virus · National Institute of Allergy and Infectious Diseases (NIAID) · Infectious Disease
  Norwalk virus is a live attenuated viral vaccine candidate that stimulates immune responses against norovirus infection.
• Zostavax vaccine · Oklahoma Medical Research Foundation · Immunology / Infectious Disease
  Zostavax is a live attenuated vaccine that stimulates the immune system to prevent herpes zoster (shingles) by boosting varicella-zoster virus (VZV)-specific cell-mediated immunity.
• RotaTeq · National Institute of Pediatrics, Mexico · Immunology / Infectious Disease
  RotaTeq is a live attenuated rotavirus vaccine that stimulates the immune system to produce antibodies and cellular immunity against rotavirus.
• Live Smallpox Vaccine · Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" · Immunology / Infectious Disease
  Live Smallpox Vaccine stimulates adaptive immune responses by introducing live attenuated vaccinia virus to generate protective antibodies and cell-mediated immunity against smallpox.
• Live Attenuated H1N1 Influenza Vaccine · University of Rochester · Immunology
  A live attenuated influenza vaccine that contains weakened H1N1 virus strains to stimulate immune response without causing disease.
• varicella-5 · Changchun Keygen Biological Products Co., Ltd. · Immunology / Infectious Disease
  Varicella-5 is a live attenuated varicella-zoster virus vaccine that stimulates immune responses to prevent chickenpox infection.
• Rotavirus Vaccine (ROTARIX) · International Centre for Diarrhoeal Disease Research, Bangladesh · Immunology / Infectious Disease
  ROTARIX is a live attenuated rotavirus vaccine that stimulates the immune system to produce antibodies and cellular immunity against rotavirus infection.
• Rotateq vaccine · University Hospital, Brest · Immunology / Infectious Disease
  RotaTeq is a live attenuated rotavirus vaccine that stimulates the immune system to produce antibodies and cellular immunity against rotavirus infection.
• bOPV · Aga Khan University · Immunology / Infectious Disease
  bOPV is an oral polio vaccine containing live attenuated poliovirus types 1 and 3 that induces mucosal and systemic immunity against poliomyelitis.
• Oral Polio Vaccine · International Centre for Diarrhoeal Disease Research, Bangladesh · Immunology / Infectious Disease
  Oral Polio Vaccine stimulates the immune system to produce antibodies against poliovirus by delivering live attenuated (weakened) poliovirus strains orally.
• varicella-3 · Beijing Center for Disease Control and Prevention · Immunology / Infectious Disease
  Varicella-3 is a live attenuated varicella-zoster virus vaccine that stimulates immune responses to prevent chickenpox infection.
• Attenuated HAV Vaccine, L-A-1 Strain · Institute of Medical Biology, Chinese Academy of Medical Sciences · Immunology / Infectious Disease
  This attenuated live vaccine stimulates immune responses against hepatitis A virus by introducing a weakened form of the virus that replicates in the body without causing disease.
• MMRvaxpro · Rigshospitalet, Denmark · Immunology / Infectious Disease
  MMRvaxpro is a live attenuated vaccine that stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses.
• mOPV type 2 · University of Chile · Immunology / Infectious Disease
  mOPV type 2 is a live attenuated oral polio vaccine that stimulates immune responses against poliovirus type 2 through mucosal and systemic immunity.
• varicella-6 · Beijing Center for Disease Control and Prevention · Immunology / Infectious Disease
  Varicella-6 is a live attenuated varicella-zoster virus vaccine that stimulates immune responses to prevent varicella (chickenpox) infection.
• Mumps vaccine, Live (MV) · Sinovac Biotech Co., Ltd · Immunology
  A live attenuated mumps virus vaccine that stimulates the immune system to produce antibodies and cellular immunity against mumps virus.

Phase 3 pipeline (58)

• VARIVAX™ New Seed Process · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  VARIVAX is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection.
• VarilrixTM · GlaxoSmithKline · Infectious Diseases
  VarilrixTM is a live attenuated vaccine that helps prevent chickenpox.
• Varivax/ProVarivax · GlaxoSmithKline · Immunology / Infectious Disease
  Varivax is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection.
• Human Rotavirus, live attenuated · Sanofi Pasteur, a Sanofi Company · Immunology / Infectious Disease
  A live attenuated rotavirus vaccine that replicates in the intestinal tract to stimulate immune responses against rotavirus without causing severe disease.
• Measles-mumps-rubella-varicella vaccine · Sanofi Pasteur, a Sanofi Company · Immunology / Infectious Disease
  This vaccine stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, rubella, and varicella viruses by introducing attenuated (weakened) forms of all four viruses.
• GSK MMR Vaccine (PRIORIX) · Shanghai Institute Of Biological Products · Immunology / Infectious Disease
  PRIORIX is a live attenuated vaccine that stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses.
• Yellow fever vaccine (live) · Sanofi Pasteur, a Sanofi Company · Immunology
  The live yellow fever vaccine stimulates an immune response by introducing a weakened form of the yellow fever virus, allowing the body to develop immunity.
• M-M-R II vaccine · Sanofi · Immunology
  M-M-R II is a live attenuated vaccine that stimulates the immune system to produce antibodies and cellular immunity against measles, mumps, and rubella viruses.
• BCG vaccine (Freeze-dried) · Tuberculosis Research Centre, India · Immunology / Infectious Disease
  BCG vaccine stimulates the immune system to recognize and attack Mycobacterium tuberculosis by activating T-cell and macrophage-mediated immunity.
• Investigational live attenuated mumps vaccine · Sinovac Research and Development Co., Ltd. · Immunology
  A live attenuated mumps vaccine stimulates the immune system to recognize and protect against mumps virus infection by using a weakened form of the virus.
• Marketed varicella vaccine_Lot 1 · GlaxoSmithKline · Immunology / Infectious Disease
  The varicella vaccine stimulates the immune system to produce antibodies and cellular immunity against the varicella-zoster virus, preventing chickenpox infection.
• PriorixTetra™ · GlaxoSmithKline · Infectious Diseases
  PriorixTetra is a live attenuated vaccine that stimulates the body's immune system to produce antibodies against measles, mumps, rubella, and varicella.
• BCG Tokyo-172 Strain Vaccine · SWOG Cancer Research Network · Oncology
  BCG Tokyo-172 is a live attenuated Mycobacterium bovis vaccine that stimulates innate and adaptive immune responses to enhance anti-tumor immunity.
• HRV Liquid · GlaxoSmithKline · Immunology / Infectious Disease
  HRV Liquid is a live attenuated human rotavirus vaccine administered orally to prevent rotavirus gastroenteritis.
• ZOSTAVAX™ (Nonconcomitant) · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  ZOSTAVAX is a live attenuated vaccine that stimulates the immune system to prevent herpes zoster (shingles) by boosting varicella-zoster virus (VZV)-specific cell-mediated immunity.
• Human rotavirus liquid vaccine · GlaxoSmithKline · Immunology / Infectious Disease
  This live attenuated rotavirus vaccine stimulates the immune system to produce antibodies and cellular immunity against rotavirus, preventing infection and severe gastroenteritis.
• Investigational varicella vaccine_Lot 2 · GlaxoSmithKline · Immunology / Infectious Disease
  This vaccine stimulates the immune system to recognize and prevent varicella-zoster virus infection by inducing protective antibodies and cell-mediated immunity.
• MMR (Priorix®) · GlaxoSmithKline · Immunology / Infectious Disease
  MMR (Priorix) is a live attenuated vaccine that stimulates the immune system to produce antibodies against measles, mumps, and rubella viruses.
• HRV Lyophilized · GlaxoSmithKline · Immunology / Infectious Disease
  HRV Lyophilized is a live attenuated human rotavirus vaccine that stimulates immune responses against rotavirus infection.
• Human rotavirus RIX4414 strain vaccine · Sanofi Pasteur, a Sanofi Company · Immunology / Infectious Disease
  This live attenuated rotavirus vaccine stimulates the immune system to produce antibodies and cellular immunity against rotavirus, preventing infection and severe gastroenteritis.
• IMOJEV · SK Bioscience Co., Ltd. · Infectious Disease / Immunology
  IMOJEV is a live attenuated Japanese encephalitis virus vaccine that stimulates immune responses to prevent Japanese encephalitis infection.
• JE-VAX® · Sanofi · Infectious Disease / Immunology
  JE-VAX is a live attenuated vaccine that stimulates immune response against Japanese encephalitis virus.
• ORV 116E · Bharat Biotech International Limited · Immunology / Infectious Disease
  ORV 116E is an oral rotavirus vaccine candidate designed to provide immunization against rotavirus infection.
• MTBVAC · International AIDS Vaccine Initiative · Immunology / Infectious Disease
  MTBVAC is a live attenuated tuberculosis vaccine that stimulates immune responses against Mycobacterium tuberculosis to prevent active TB disease.
• BCG Vaccine IP - Serum Institute of India · Green Signal Biopharma Private Limited · Immunology / Infectious Disease
  BCG vaccine stimulates the immune system to recognize and attack tuberculosis-causing bacteria through activation of T-cells and macrophages.
• Candidate varicella vaccine · GlaxoSmithKline · Immunology / Infectious Disease
  A live attenuated varicella-zoster virus vaccine that stimulates immune responses to prevent chickenpox and herpes zoster infection.
• VARIVAX® PE34 Process · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  VARIVAX PE34 Process is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox and herpes zoster infection.
• Local OPV · GlaxoSmithKline · Immunology / Infectious Disease
  Local OPV is an oral polio vaccine that provides immunization against poliovirus through oral administration of live attenuated virus.
• Comparator: Varicella Zoster Virus Vaccine · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  This vaccine stimulates the immune system to produce antibodies and cellular immunity against varicella zoster virus, preventing chickenpox and herpes zoster infection.
• Live attenuated SA 14-14-2 vaccine · PATH · Immunology / Infectious Disease
  A live attenuated Japanese encephalitis virus vaccine that stimulates immune responses against Japanese encephalitis virus through controlled viral replication.
• SII Yellow Fever Vaccine · Serum Institute of India Pvt. Ltd. · Immunology / Infectious Disease
  This live attenuated yellow fever vaccine stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus.
• Stamaril™ · GlaxoSmithKline · Immunology / Infectious Disease
  Stamaril is a live attenuated yellow fever vaccine that stimulates the immune system to produce antibodies and cellular immunity against yellow fever virus.
• RotaTeq™ existing formulation · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  RotaTeq is a live attenuated rotavirus vaccine that stimulates immune responses to prevent rotavirus gastroenteritis.
• ROTAVIN (liquid formulation) · Center for Research and Production of Vaccines and Biologicals, Vietnam · Immunology / Infectious Disease
  ROTAVIN is a live attenuated rotavirus vaccine that stimulates the immune system to produce antibodies and cellular immunity against rotavirus infection.
• Marketed varicella vaccine_Lot 2 · GlaxoSmithKline · Immunology / Infectious Disease
  This live attenuated varicella-zoster virus vaccine stimulates the immune system to produce antibodies and cell-mediated immunity against varicella (chickenpox).
• Merck and Company's MMRII · GlaxoSmithKline · Immunology / Infectious Disease
  M-M-R II is a live attenuated vaccine that stimulates immune response against measles, mumps, and rubella viruses.
• Merck and Company's Varivax · GlaxoSmithKline · Immunology / Infectious Disease
  Varivax is a live attenuated varicella-zoster virus vaccine that stimulates immune response to prevent chickenpox infection.
• Live attenuated influenza virus · Turku University Hospital · Immunology / Infectious Disease
  Live attenuated influenza virus vaccine stimulates immune responses by delivering weakened virus that replicates in the respiratory tract without causing severe disease.
• JECEVAX · National Institute of Hygiene and Epidemiology, Vietnam · Immunology / Infectious Disease
  JECEVAX is a live attenuated Japanese encephalitis vaccine that stimulates immune responses against Japanese encephalitis virus.
• Comparator: M-M-R II · Merck Sharp & Dohme LLC · Immunology / Infectious Disease
  M-M-R II is a live attenuated viral vaccine that stimulates immune response against measles, mumps, and rubella by introducing weakened forms of these viruses.

Phase 2 pipeline (2)

• BCG vial vaccine · PT Bio Farma · Infectious Disease
  Stimulates a cell-mediated immune response against Mycobacterium tuberculosis
• CAIV-T 10^7 · MedImmune LLC · Infectious Disease
  CAIV-T 10^7 is a live attenuated influenza vaccine.