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Local OPV
Local OPV is an oral polio vaccine that provides immunization against poliovirus through oral administration of live attenuated virus.
Local OPV is an oral polio vaccine that provides immunization against poliovirus through oral administration of live attenuated virus. Used for Poliomyelitis prevention.
At a glance
| Generic name | Local OPV |
|---|---|
| Also known as | oral poliovirus vaccine |
| Sponsor | GlaxoSmithKline |
| Drug class | Live attenuated vaccine |
| Target | Poliovirus (types 1, 2, and/or 3) |
| Modality | Biologic |
| Therapeutic area | Immunology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
OPV (Oral Polio Vaccine) contains live attenuated poliovirus strains that replicate in the intestinal tract, stimulating both mucosal and systemic immune responses. This generates antibodies and cellular immunity against wild-type poliovirus. The 'local' designation may refer to a regionally-adapted or locally-produced formulation by GSK.
Approved indications
- Poliomyelitis prevention
Common side effects
- Vaccine-associated paralytic poliomyelitis (VAPP)
- Local injection site reactions
- Fever
- Gastrointestinal symptoms
Key clinical trials
- Vaccine Campaign Effects on General Hospital Admissions and Mortality Among Children (PHASE4)
- To Develop, Implement and Evaluate the Polio Demonstration Project Comprising of a Community Based Intervention Package for Polio Eradication in Pakistan (PHASE4)
- Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age. (PHASE3)
- Immunogenicity and Safety of Imovax Polio in Chinese Infants Compared to Local OPV (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Local OPV CI brief — competitive landscape report
- Local OPV updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI