{"id":"local-opv","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaccine-associated paralytic poliomyelitis (VAPP)"},{"rate":null,"effect":"Local injection site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Gastrointestinal symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"OPV (Oral Polio Vaccine) contains live attenuated poliovirus strains that replicate in the intestinal tract, stimulating both mucosal and systemic immune responses. This generates antibodies and cellular immunity against wild-type poliovirus. The 'local' designation may refer to a regionally-adapted or locally-produced formulation by GSK.","oneSentence":"Local OPV is an oral polio vaccine that provides immunization against poliovirus through oral administration of live attenuated virus.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:19:20.183Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Poliomyelitis prevention"}]},"trialDetails":[{"nctId":"NCT03460002","phase":"PHASE4","title":"Vaccine Campaign Effects on General Hospital Admissions and Mortality Among Children","status":"COMPLETED","sponsor":"Bandim Health Project","startDate":"2016-11","conditions":"Measles Vaccination, Oral Polio Vaccine, Non-specific/Heterologous Effects of Vaccines","enrollment":28612},{"nctId":"NCT01908114","phase":"PHASE4","title":"To Develop, Implement and Evaluate the Polio Demonstration Project Comprising of a Community Based Intervention Package for Polio Eradication in Pakistan","status":"UNKNOWN","sponsor":"Aga Khan University","startDate":"2013-07","conditions":"Polio, Polio Sero Conversion, Polio Sero Prevalence","enrollment":60000},{"nctId":"NCT00829010","phase":"PHASE3","title":"Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age.","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2009-02-17","conditions":"Infections, Streptococcal","enrollment":489},{"nctId":"NCT00348387","phase":"PHASE3","title":"Immunogenicity and Safety of Imovax Polio in Chinese Infants Compared to Local OPV","status":"COMPLETED","sponsor":"Sanofi Pasteur, a Sanofi Company","startDate":"2006-06","conditions":"Poliomyelitis, Polio","enrollment":600}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":229,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["oral poliovirus vaccine"],"phase":"phase_3","status":"active","brandName":"Local OPV","genericName":"Local OPV","companyName":"GlaxoSmithKline","companyId":"glaxosmithkline","modality":"Biologic","firstApprovalDate":"","aiSummary":"Local OPV is an oral polio vaccine that provides immunization against poliovirus through oral administration of live attenuated virus. Used for Poliomyelitis prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}