Imidazole antifungal

This page covers all Imidazole antifungal drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Lanosterol 14α-demethylase (CYP51), Fungal cytochrome P450 (CYP51 / lanosterol 14α-demethylase), Fungal lanosterol 14α-demethylase (CYP51).

Targets

Lanosterol 14α-demethylase (CYP51) · Fungal cytochrome P450 (CYP51 / lanosterol 14α-demethylase) · Fungal lanosterol 14α-demethylase (CYP51) · 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, Malate dehydrogenase cytoplasmic , 5-hydroxytryptamine receptor 6 · Fungal cytochrome P450 (lanosterol 14α-demethylase)

Marketed (13)

• Topical Sertaconazole 2% · Jinnah Postgraduate Medical Centre · Dermatology / Infectious Disease
  Sertaconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.
• Nizoral® · Ache Laboratorios Farmaceuticos S.A. · Infectious Disease
  Nizoral inhibits fungal cytochrome P450 enzymes, disrupting ergosterol synthesis in the fungal cell membrane and causing cell death.
• Luliconazole Cream 1% · Bausch Health Americas, Inc. · Dermatology
  Luliconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.
• Ketoconazole 2% Shampoo · Fakultas Kedokteran Universitas Indonesia · Dermatology
  Ketoconazole inhibits fungal cytochrome P450 enzymes, disrupting ergosterol synthesis in fungal cell membranes and causing cell death.
• Topical Clotrimazole cream · Hayat Abad Medical Complex, Peshawar · Dermatology / Infectious Disease
  Clotrimazole inhibits fungal cell membrane synthesis by blocking ergosterol production, disrupting the integrity and function of the fungal cell membrane.
• Monistat · Johnson & Johnson (Janssen) · Infectious Disease
• Bifonazole Cream · Galderma R&D · Dermatology / Infectious Disease
  Bifonazole is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.
• Topical ketoconazole 2% cream · PAEC General Hospital, Islamabad · Dermatology / Infectious Disease
  Ketoconazole inhibits fungal cytochrome P450 enzymes, disrupting ergosterol synthesis in the fungal cell membrane and causing cell death.
• Ketoconazole 2% · University of California, Davis · Infectious Disease / Dermatology
  Ketoconazole inhibits fungal cytochrome P450 enzymes, disrupting ergosterol synthesis in the fungal cell membrane and causing cell death.
• Clotrimazole 1% · Jinnah Postgraduate Medical Centre · Infectious Disease
  Clotrimazole inhibits fungal cell membrane synthesis by blocking the conversion of lanosterol to ergosterol via inhibition of fungal cytochrome P450 enzymes.
• clotrimazole vaginal tablets · Peking University Shenzhen Hospital · Infectious Disease
  Clotrimazole disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death.
• Miconazole Nitrate 2% · Aesculape CRO Belgium BV · Dermatology / Infectious Disease
  Miconazole nitrate disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death.
• Canesten® · Ache Laboratorios Farmaceuticos S.A. · Infectious Disease
  Canesten inhibits fungal cell membrane synthesis by blocking ergosterol production through inhibition of lanosterol 14α-demethylase.

Phase 3 pipeline (7)

• Bifonazole cream 1% · Bayer · Dermatology
  Bifonazole inhibits fungal cell membrane synthesis by disrupting ergosterol production through inhibition of lanosterol 14α-demethylase.
• Econazole Nitrate Foam 1% · AmDerma · Dermatology
  Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.
• GYNODAKTARIN® · Laboratoire Innotech International · Dermatology / Infectious Disease
  GYNODAKTARIN is an antifungal agent that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.
• Sertaconazole nitrate cream 2% · Jamaica Hospital Medical Center · Dermatology
  Sertaconazole nitrate inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal growth and viability.
• ketoconazole shampoo (2/week) · Galderma R&D · Dermatology
  Ketoconazole shampoo inhibits fungal growth by disrupting ergosterol synthesis in fungal cell membranes, reducing dandruff and seborrheic dermatitis.
• Clotrimazole, vaginal ovule · Bayer · Infectious Disease
  Clotrimazole disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis, leading to cell death.
• Econazole Nitrate Cream 1% · AmDerma · Dermatology / Infectious Disease
  Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.

Patent intelligence

• imidazole antifungal patent landscape — aggregated cliff calendar, attackable patents, originator estates