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Econazole Nitrate Cream 1%
Econazole Nitrate Cream 1% is a Imidazole antifungal Small molecule drug developed by AmDerma. It is currently in Phase 3 development for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch). Also known as: Econazole Nitrate Cream 1%, Fougera - Altana Inc..
Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.
Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).
At a glance
| Generic name | Econazole Nitrate Cream 1% |
|---|---|
| Also known as | Econazole Nitrate Cream 1%, Fougera - Altana Inc. |
| Sponsor | AmDerma |
| Drug class | Imidazole antifungal |
| Target | Lanosterol 14α-demethylase (CYP51) |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Econazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. This disruption leads to increased membrane permeability and leakage of cellular contents, ultimately causing fungal cell death. The topical cream formulation delivers the active agent directly to affected skin areas.
Approved indications
- Tinea pedis (athlete's foot)
- Tinea corporis (ringworm)
- Tinea cruris (jock itch)
- Candidiasis (cutaneous yeast infections)
- Pityriasis versicolor
Common side effects
- Burning or stinging at application site
- Erythema
- Pruritus
- Contact dermatitis
Key clinical trials
- Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis (PHASE3)
- Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream (PHASE1)
- A Study of Econazole Foam 1% in Athlete's Foot (PHASE2)
- Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 Years to Less Than 18 Years (PHASE2)
- Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Econazole Nitrate Cream 1% CI brief — competitive landscape report
- Econazole Nitrate Cream 1% updates RSS · CI watch RSS
- AmDerma portfolio CI
Frequently asked questions about Econazole Nitrate Cream 1%
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Related
- Drug class: All Imidazole antifungal drugs
- Target: All drugs targeting Lanosterol 14α-demethylase (CYP51)
- Manufacturer: AmDerma — full pipeline
- Therapeutic area: All drugs in Dermatology / Infectious Disease
- Indication: Drugs for Tinea pedis (athlete's foot)
- Indication: Drugs for Tinea corporis (ringworm)
- Indication: Drugs for Tinea cruris (jock itch)
- Also known as: Econazole Nitrate Cream 1%, Fougera - Altana Inc.
- Compare: Econazole Nitrate Cream 1% vs similar drugs
- Pricing: Econazole Nitrate Cream 1% cost, discount & access