{"id":"econazole-nitrate-cream-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1201049","moleculeType":"Small molecule","molecularWeight":"444.70"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Econazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. This disruption leads to increased membrane permeability and leakage of cellular contents, ultimately causing fungal cell death. The topical cream formulation delivers the active agent directly to affected skin areas.","oneSentence":"Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:09:59.455Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"},{"name":"Candidiasis (cutaneous yeast infections)"},{"name":"Pityriasis versicolor"}]},"trialDetails":[{"nctId":"NCT03129321","phase":"PHASE3","title":"Therapeutic Equivalence and Safety of Two Econazole Nitrate Cream, 1% Products in Tinea Pedis","status":"COMPLETED","sponsor":"Mylan Inc.","startDate":"2016-03-15","conditions":"Tinea Pedis","enrollment":876},{"nctId":"NCT02713893","phase":"PHASE1","title":"Tolerability and Pharmacokinetic Study of Econazole Nitrate and Benzydamine HCl Intravaginal Cream","status":"COMPLETED","sponsor":"Aziende Chimiche Riunite Angelini Francesco S.p.A","startDate":"2015-09","conditions":"Healthy","enrollment":48},{"nctId":"NCT00768599","phase":"PHASE2","title":"A Study of Econazole Foam 1% in Athlete's Foot","status":"COMPLETED","sponsor":"AmDerma","startDate":"2008-03","conditions":"Tinea Pedis, Athlete's Foot","enrollment":135},{"nctId":"NCT01696799","phase":"PHASE2","title":"Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 Years to Less Than 18 Years","status":"COMPLETED","sponsor":"AmDerma","startDate":"2011-09","conditions":"Interdigital Tinea Pedis","enrollment":42},{"nctId":"NCT01358240","phase":"PHASE3","title":"Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis","status":"COMPLETED","sponsor":"AmDerma","startDate":"2011-06","conditions":"Tinea Pedis, Athlete's Foot","enrollment":336}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Econazole Nitrate Cream 1%, Fougera - Altana Inc."],"phase":"phase_3","status":"active","brandName":"Econazole Nitrate Cream 1%","genericName":"Econazole Nitrate Cream 1%","companyName":"AmDerma","companyId":"amderma","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}