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Sertaconazole nitrate cream 2%
Sertaconazole nitrate inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal growth and viability.
Sertaconazole nitrate inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal growth and viability. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).
At a glance
| Generic name | Sertaconazole nitrate cream 2% |
|---|---|
| Also known as | Ertaczo cream 2% |
| Sponsor | Jamaica Hospital Medical Center |
| Drug class | Imidazole antifungal |
| Target | Lanosterol 14α-demethylase (CYP51) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
As an imidazole antifungal, sertaconazole nitrate targets the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in fungi, preventing the conversion of lanosterol to ergosterol. This disruption of ergosterol synthesis compromises the integrity and fluidity of the fungal cell membrane, leading to cell death. The topical cream formulation delivers high local concentrations to affected skin areas while minimizing systemic exposure.
Approved indications
- Tinea pedis (athlete's foot)
- Tinea corporis (ringworm)
- Tinea cruris (jock itch)
- Cutaneous candidiasis
Common side effects
- Contact dermatitis
- Burning or stinging at application site
- Erythema
- Pruritus
Key clinical trials
- Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis (PHASE4)
- Sertaconazole 2% Cream to Improve Symptoms Associated With Atopic Dermatitis (PHASE2)
- Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
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- Sertaconazole nitrate cream 2% CI brief — competitive landscape report
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- Jamaica Hospital Medical Center portfolio CI