{"id":"sertaconazole-nitrate-cream-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"As an imidazole antifungal, sertaconazole nitrate targets the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in fungi, preventing the conversion of lanosterol to ergosterol. This disruption of ergosterol synthesis compromises the integrity and fluidity of the fungal cell membrane, leading to cell death. The topical cream formulation delivers high local concentrations to affected skin areas while minimizing systemic exposure.","oneSentence":"Sertaconazole nitrate inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal growth and viability.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:05.021Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"},{"name":"Cutaneous candidiasis"}]},"trialDetails":[{"nctId":"NCT06869681","phase":"PHASE4","title":"Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2025-03-01","conditions":"Tinea Pedis","enrollment":100},{"nctId":"NCT01792713","phase":"PHASE2","title":"Sertaconazole 2% Cream to Improve Symptoms Associated With Atopic Dermatitis","status":"COMPLETED","sponsor":"Spirig Pharma Ltd.","startDate":"2013-02","conditions":"Skin Alterations Associated With Atopic Dermatitis","enrollment":70},{"nctId":"NCT00856596","phase":"PHASE3","title":"Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females","status":"UNKNOWN","sponsor":"Jamaica Hospital Medical Center","startDate":"2009-03","conditions":"Tinea Pedis, Athlete's Foot, Foot Fungus","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ertaczo cream 2%"],"phase":"phase_3","status":"active","brandName":"Sertaconazole nitrate cream 2%","genericName":"Sertaconazole nitrate cream 2%","companyName":"Jamaica Hospital Medical Center","companyId":"jamaica-hospital-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sertaconazole nitrate inhibits fungal cell membrane ergosterol synthesis by blocking lanosterol 14α-demethylase, disrupting fungal growth and viability. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}