Last reviewed 2026-05-13 · How we verify

Econazole Nitrate Foam 1%

Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis.

Econazole nitrate is an imidazole antifungal that disrupts fungal cell membrane integrity by inhibiting ergosterol synthesis. Used for Tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).

At a glance

Mechanism of action

Econazole inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. This disruption leads to increased membrane permeability and leakage of cellular contents, ultimately causing fungal cell death. The foam formulation provides enhanced topical delivery and coverage for affected skin areas.

Approved indications

• Tinea pedis (athlete's foot)
• Tinea corporis (ringworm)
• Tinea cruris (jock itch)
• Cutaneous candidiasis

Common side effects

• Application site irritation
• Burning or stinging at application site
• Erythema
• Pruritus

Key clinical trials

• Safety and Efficacy of Econazole Nitrate Foam 1% in Subjects With Tinea Pedis (PHASE3)
• A Study of Econazole Foam 1% in Athlete's Foot (PHASE2)
• Comparative PK Study of Econazole Nitrate Foam and Econazole Nitrate Cream in Subjects With Interdigital Tinea Pedis Aged 12 Years to Less Than 18 Years (PHASE2)
• Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis (PHASE3)

Primary sources

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