General anesthetic combination

This page covers all General anesthetic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Mu opioid receptor (remifentanil); GABA-A receptor (propofol); Voltage-gated sodium channels (prilocaine), Mu-opioid receptor (remifentanil), alpha-2 adrenergic receptor (dexmedetomidine), GABA and other CNS targets (desflurane), Mu-opioid receptor (remifentanil); GABA-A receptor (propofol); multiple ion channels and neurotransmitter receptors (desflurane).

Targets

Mu opioid receptor (remifentanil); GABA-A receptor (propofol); Voltage-gated sodium channels (prilocaine) · Mu-opioid receptor (remifentanil), alpha-2 adrenergic receptor (dexmedetomidine), GABA and other CNS targets (desflurane) · Mu-opioid receptor (remifentanil); GABA-A receptor (propofol); multiple ion channels and neurotransmitter receptors (desflurane) · GABA-A receptor · NMDA receptor antagonist (ketamine) and GABA-A receptor agonist (propofol)

Marketed (5)

• Remifentanil, propofol and citanest · University of Aarhus · Anesthesiology
  This is a combination of three anesthetic agents that work synergistically to induce and maintain general anesthesia through different mechanisms.
• Remifentanil, Dexmedetomidine, and Desflurane · The Cooper Health System · Anesthesiology
  This is a combination of three anesthetic agents that work synergistically: remifentanil (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and desflurane (volatile anesthetic) to produce sedation, analgesia, and unconsciousness for surgical procedures.
• Remifentanil, Propofol, and Desflurane · The Cooper Health System · Anesthesiology
  This is a combination of three anesthetic agents that work together to induce and maintain general anesthesia through different mechanisms: remifentanil provides opioid analgesia, propofol induces sedation via GABA potentiation, and desflurane maintains anesthesia via volatile anesthetic action.
• Sevoflurane+Propofol · Huazhong University of Science and Technology · Anesthesiology
  Sevoflurane and propofol are combined inhalational and intravenous anesthetics that enhance GABAergic inhibitory neurotransmission to produce sedation, hypnosis, and anesthesia.
• Ketofol as induction agent · Fayoum University Hospital · Anesthesiology
  Ketofol is a combination of ketamine and propofol that produces rapid anesthesia by blocking NMDA receptors and enhancing GABAergic inhibition simultaneously.

Phase 3 pipeline (2)

• General anesthesia and opioids · The Cleveland Clinic · Anesthesiology
  This is a combination approach using general anesthetic agents alongside opioid medications to induce and maintain unconsciousness and analgesia during surgical procedures.
• Propofol+ Rocuronium+ Fentanyl + Inhalational · Memorial Sloan Kettering Cancer Center · Anesthesiology
  This is a combination anesthetic regimen that induces unconsciousness, provides muscle paralysis, and delivers pain relief for surgical procedures.