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Sevoflurane+Propofol
Sevoflurane and propofol are combined inhalational and intravenous anesthetics that enhance GABAergic inhibitory neurotransmission to produce sedation, hypnosis, and anesthesia.
Sevoflurane and propofol are combined inhalational and intravenous anesthetics that enhance GABAergic inhibitory neurotransmission to produce sedation, hypnosis, and anesthesia. Used for General anesthesia for surgical procedures, Sedation during anesthesia maintenance.
At a glance
| Generic name | Sevoflurane+Propofol |
|---|---|
| Also known as | Sevoflurane and Propofol |
| Sponsor | Huazhong University of Science and Technology |
| Drug class | General anesthetic combination |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a volatile anesthetic that potentiates GABA-A receptor signaling in the central nervous system, while propofol is an intravenous anesthetic with similar GABAergic mechanisms. Together, they provide synergistic anesthetic effects, allowing for reduced dosing of each agent while maintaining adequate anesthesia during surgical procedures. This combination is used to optimize the balance between anesthetic depth and hemodynamic stability.
Approved indications
- General anesthesia for surgical procedures
- Sedation during anesthesia maintenance
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Emergence delirium
- Postoperative nausea and vomiting
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Propofol Versus Sevoflurane Anesthesia on the Intraocular Pressure and Hemodynamics in Patient Undergoing Cyclophotocoagulation (NA)
- Deep Versus Moderate Neuromuscular Blocking (NA)
- Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke (NA)
- The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients (NA)
- Equivalent MAC in General Anesthesia
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Comparison of Gastric Insufflation Volume Between LarySeal Pro and Ambu AuraGain Using Ultrasonography In Pediatric Patients Undergoing General Anesthesia With Controlled Ventilation. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane+Propofol CI brief — competitive landscape report
- Sevoflurane+Propofol updates RSS · CI watch RSS
- Huazhong University of Science and Technology portfolio CI