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Remifentanil, Dexmedetomidine, and Desflurane
Remifentanil, Dexmedetomidine, and Desflurane is a General anesthetic combination Small molecule drug developed by The Cooper Health System. It is currently FDA-approved for General anesthesia for surgical procedures, Sedation and analgesia during anesthesia maintenance. Also known as: Ultiva, Suprane, Precedex.
This is a combination of three anesthetic agents that work synergistically: remifentanil (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and desflurane (volatile anesthetic) to produce sedation, analgesia, and unconsciousness for surgical procedures.
This is a combination of three anesthetic agents that work synergistically: remifentanil (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and desflurane (volatile anesthetic) to produce sedation, analgesia, and unconsciousness for surgical procedures. Used for General anesthesia for surgical procedures, Sedation and analgesia during anesthesia maintenance.
At a glance
| Generic name | Remifentanil, Dexmedetomidine, and Desflurane |
|---|---|
| Also known as | Ultiva, Suprane, Precedex |
| Sponsor | The Cooper Health System |
| Drug class | General anesthetic combination |
| Target | Mu-opioid receptor (remifentanil), alpha-2 adrenergic receptor (dexmedetomidine), GABA and other CNS targets (desflurane) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Remifentanil binds to mu-opioid receptors to provide rapid-onset analgesia and sedation. Dexmedetomidine activates alpha-2 adrenergic receptors in the central nervous system to produce sedation and anxiolysis with preserved airway reflexes. Desflurane is a volatile anesthetic that enhances CNS depression and unconsciousness. Together, these agents provide balanced anesthesia with complementary mechanisms for induction and maintenance during surgery.
Approved indications
- General anesthesia for surgical procedures
- Sedation and analgesia during anesthesia maintenance
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Emergence delirium
- Nausea and vomiting
Key clinical trials
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia (NA)
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
- Opioid-Free Anesthesia in Cardiac Surgery (PHASE3)
- Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery (NA)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study
- Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Remifentanil, Dexmedetomidine, and Desflurane CI brief — competitive landscape report
- Remifentanil, Dexmedetomidine, and Desflurane updates RSS · CI watch RSS
- The Cooper Health System portfolio CI
Frequently asked questions about Remifentanil, Dexmedetomidine, and Desflurane
What is Remifentanil, Dexmedetomidine, and Desflurane?
How does Remifentanil, Dexmedetomidine, and Desflurane work?
What is Remifentanil, Dexmedetomidine, and Desflurane used for?
Who makes Remifentanil, Dexmedetomidine, and Desflurane?
Is Remifentanil, Dexmedetomidine, and Desflurane also known as anything else?
What drug class is Remifentanil, Dexmedetomidine, and Desflurane in?
What development phase is Remifentanil, Dexmedetomidine, and Desflurane in?
What are the side effects of Remifentanil, Dexmedetomidine, and Desflurane?
What does Remifentanil, Dexmedetomidine, and Desflurane target?
Related
- Drug class: All General anesthetic combination drugs
- Target: All drugs targeting Mu-opioid receptor (remifentanil), alpha-2 adrenergic receptor (dexmedetomidine), GABA and other CNS targets (desflurane)
- Manufacturer: The Cooper Health System — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for General anesthesia for surgical procedures
- Indication: Drugs for Sedation and analgesia during anesthesia maintenance
- Also known as: Ultiva, Suprane, Precedex
- Compare: Remifentanil, Dexmedetomidine, and Desflurane vs similar drugs
- Pricing: Remifentanil, Dexmedetomidine, and Desflurane cost, discount & access