Who is sponsoring NCT05411159?

NCT05411159 is sponsored by Beijing Chao Yang Hospital.

What drugs are being tested in NCT05411159?

Interventions in NCT05411159: Opioid-Free Anesthesia (OFA), Standard general anesthesia (OA).

What condition does NCT05411159 study?

NCT05411159 studies Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases.

Is NCT05411159 still recruiting?

NCT05411159 is currently completed. Last updated 19 March 2025.

Last reviewed 2025-03-19 · How we verify

NCT05411159: OFA-PONV

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery

Completed NA Last updated 19 March 2025

What this trial tests

NA trial testing Opioid-Free Anesthesia (OFA) in Postoperative Nausea and Vomiting in 168 participants. Completed in 30 November 2024.

Timeline

7 June 2022

Primary endpoint
30 April 2024

30 November 2024

Quick facts

Lead sponsor	Beijing Chao Yang Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	168
Start date	7 June 2022
Primary completion	30 April 2024
Estimated completion	30 November 2024
Sites	1 location across China

Drugs / interventions tested

Opioid-Free Anesthesia (OFA)
Standard general anesthesia (OA)

Conditions studied

Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →
Opioid Use — all drugs for Opioid Use →
Thoracic Diseases — all drugs for Thoracic Diseases →

Sponsor

Beijing Chao Yang Hospital

Who can join

Adults 18 to 65, any sex, with Postoperative Nausea and Vomiting or Opioid Use. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aimed to verify whether an Opioid-free Anesthesia (OFA) could effectively reduce the incidence of PONV after thoracoscopic-assisted surgery compared with standard general anesthesia (OA) regimens.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of balanced opioid-free anesthesia on post-operative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized trial.
Yan X, Liang C, Jiang J, Ji Y, et al · · 2025 · cited 2× · PMID 39923016 · DOI 10.1186/s12871-025-02938-x
Effects of opioid-free anaesthesia on postoperative nausea and vomiting in patients undergoing video-assisted thoracoscopic surgery (OFA-PONV trial): study protocol for a randomised controlled trial.
Yan X, Liang C, Jiang J, Ji Y, et al · · 2023 · cited 2× · PMID 38124084 · DOI 10.1186/s13063-023-07859-z
Effect of EEG-guided opioid-free anesthesia on perioperative blood glucose variation in patients undergoing video-assisted thoracic surgery: a secondary analysis of a randomized controlled study.
Yan X, Liang C, Guo M, Jiang J, et al · · 2026 · PMID 41776687 · DOI 10.1186/s13741-026-00666-5

Verify or expand the search:

Other trials of Opioid-Free Anesthesia (OFA)

Trials testing the same drug.

NCT06915558 — Modulation of the Inflammatory Response in Bariatric Surgery · recruiting

Other Beijing Chao Yang Hospital trials

Trials by the same sponsor.

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NCT07323134 — The Effect of Semaglutide on the Intestinal Flora in Obesity · not yet recruiting
NCT07049692 — Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05411159 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Chao Yang Hospital
Last refreshed: 19 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05411159.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing