Last reviewed · How we verify
NCT07244575: Met-PONV
Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia
trial in Postoperative Nausea and Vomiting in 909 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | Sixth Affiliated Hospital, Sun Yat-sen University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 909 |
| Start date | 1 December 2025 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2033 |
| Sites | 1 location across China |
Conditions studied
- Postoperative Nausea and Vomiting — all drugs for Postoperative Nausea and Vomiting →
Sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Who can join
18 and older, any sex, with Postoperative Nausea and Vomiting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this observational study is to investigate the potential effects of metformin on postoperative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia. The primary research question is: Does preoperative metformin exposure influence the incidence or severity of PONV in patients undergoing general anesthesia? Patients who are already prescribed metformin as part of their routine medical management will be compared with those not taking metformin. Data on PONV occurrence, severity, and recovery outcomes will be collected through structured postoperative surveys administered after surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chinese tertiary hospital.
Shi J, Zheng J, Zhang X, Liang C, et al · · 2026 · PMID 42215267 · DOI 10.1136/bmjopen-2026-117537
Verify or expand the search:
- PubMed search for NCT07244575
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Postoperative Nausea and Vomiting
Currently open trials in the same condition.
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- NCT07271147 — Effects of taVNS Combined With Dexmedetomidine on POVN · NA · recruiting
- NCT07386379 — Propofol Infusion and PONV in Cardiac Surgery · recruiting
Other Sixth Affiliated Hospital, Sun Yat-sen University trials
Trials by the same sponsor.
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- NCT07510191 — TNFi Plus Low-Dose Upadacitinib vs TNFi Intensification in Crohn's Disease With Suboptimal Response · Phase 4 · recruiting
- NCT07344428 — Efficacy and Safety of CDED With Anti-TNF-α Biologics in Crohn's Disease: A Randomized Trial · NA · not yet recruiting
- NCT07328958 — Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic A · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07244575 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sixth Affiliated Hospital, Sun Yat-sen University
- Last refreshed: 9 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07244575.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing