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Together, these agents provide balanced anesthesia with complementary mechanisms for induction and maintenance during surgery.","oneSentence":"This is a combination of three anesthetic agents that work synergistically: remifentanil (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and desflurane (volatile anesthetic) to produce sedation, analgesia, and unconsciousness for surgical procedures.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:04:41.449Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia for surgical procedures"},{"name":"Sedation and analgesia during anesthesia maintenance"}]},"trialDetails":[{"nctId":"NCT07337135","phase":"NA","title":"Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery","status":"COMPLETED","sponsor":"Hospital dos Lusíadas","startDate":"2023-10-02","conditions":"Morbid Obesity, Postoperative Pain, Opioid Free Anesthesia","enrollment":60},{"nctId":"NCT07363681","phase":"NA","title":"Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia","status":"RECRUITING","sponsor":"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","startDate":"2024-10-01","conditions":"Ureterorenoscopic Lithotripsy, Transurethral Resection of the Bladder, Percutaneous Nephrolithotomy","enrollment":150},{"nctId":"NCT03756961","phase":"NA","title":"Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery","status":"RECRUITING","sponsor":"Göteborg University","startDate":"2019-05-01","conditions":"Obesity, Pain, Postoperative","enrollment":220},{"nctId":"NCT04940689","phase":"PHASE3","title":"Opioid-Free Anesthesia in Cardiac Surgery","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2021-07-22","conditions":"Anesthesia","enrollment":268},{"nctId":"NCT05411159","phase":"NA","title":"Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery","status":"COMPLETED","sponsor":"Beijing Chao Yang Hospital","startDate":"2022-06-07","conditions":"Postoperative Nausea and Vomiting, Opioid Use, Thoracic Diseases","enrollment":168},{"nctId":"NCT04894864","phase":"PHASE4","title":"Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","status":"RECRUITING","sponsor":"University of Crete","startDate":"2020-10-08","conditions":"Elective Surgical Procedures, Postoperative Pain, Anesthesia","enrollment":40},{"nctId":"NCT05785273","phase":"","title":"Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study","status":"COMPLETED","sponsor":"Università degli Studi di Brescia","startDate":"2019-02-19","conditions":"Analgesia, Anesthesia","enrollment":45},{"nctId":"NCT03996148","phase":"PHASE4","title":"Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques","status":"COMPLETED","sponsor":"The Cooper Health System","startDate":"2017-09-29","conditions":"Carotid Artery Stenosis","enrollment":21},{"nctId":"NCT02412150","phase":"NA","title":"Effect of Dexmedetomidine After Thyroidectomy","status":"COMPLETED","sponsor":"Chosun University Hospital","startDate":"2014-04","conditions":"Thyroid Tumor","enrollment":139},{"nctId":"NCT03029715","phase":"NA","title":"Anaesthesia for Laparoscopic Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2014-02","conditions":"Obese","enrollment":100},{"nctId":"NCT02464722","phase":"PHASE4","title":"Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery","status":"UNKNOWN","sponsor":"Korea University Anam Hospital","startDate":"2015-08","conditions":"Hemodynamic Instability","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ultiva","Suprane","Precedex"],"phase":"marketed","status":"active","brandName":"Remifentanil, Dexmedetomidine, and Desflurane","genericName":"Remifentanil, Dexmedetomidine, and Desflurane","companyName":"The Cooper Health System","companyId":"the-cooper-health-system","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three anesthetic agents that work synergistically: remifentanil (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and desflurane (volatile anesthetic) to produce sedation, analgesia, and unconsciousness for surgical procedures. Used for General anesthesia for surgical procedures, Sedation and analgesia during anesthesia maintenance.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}