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Ketofol as induction agent
Ketofol as induction agent is a General anesthetic combination Small molecule drug developed by Fayoum University Hospital. It is currently FDA-approved for Induction of general anesthesia in adult patients.
Ketofol is a combination of ketamine and propofol that produces rapid anesthesia by blocking NMDA receptors and enhancing GABAergic inhibition simultaneously.
Ketofol is a combination of ketamine and propofol that produces rapid anesthesia by blocking NMDA receptors and enhancing GABAergic inhibition simultaneously. Used for Induction of general anesthesia.
At a glance
| Generic name | Ketofol as induction agent |
|---|---|
| Sponsor | Fayoum University Hospital |
| Drug class | General anesthetic combination |
| Target | NMDA receptor antagonist (ketamine) and GABA-A receptor agonist (propofol) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Ketamine acts as an NMDA receptor antagonist providing dissociative anesthesia and analgesia, while propofol is a GABA-A receptor agonist that enhances inhibitory neurotransmission. The combination leverages the rapid onset and hemodynamic stability of ketamine with the smooth induction profile of propofol, reducing the dose-dependent side effects of each agent when used alone.
Approved indications
- Induction of general anesthesia in adult patients
Common side effects
- Hypotension
- Bradycardia
- Apnea
- Emergence reactions
- Pain on injection
Key clinical trials
- Effects of Different Sedation Techniques on Early Cognitive Recovery After Ambulatory Gynecologic Surgery (NA)
- Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy (NA)
- Ketofol Versus Propofol for Sedation in Cholangiopancreatography for ASA III and ASA IV Patients. (NA)
- Smooth Extubation With Ketofol for Induction of General Anesthesia in Laparoscopic Drilling of Polycystic Ovary (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ketofol as induction agent CI brief — competitive landscape report
- Ketofol as induction agent updates RSS · CI watch RSS
- Fayoum University Hospital portfolio CI
Frequently asked questions about Ketofol as induction agent
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Related
- Drug class: All General anesthetic combination drugs
- Target: All drugs targeting NMDA receptor antagonist (ketamine) and GABA-A receptor agonist (propofol)
- Manufacturer: Fayoum University Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction of general anesthesia in adult patients
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing