Last reviewed · How we verify
General anesthesia and opioids
This is a combination approach using general anesthetic agents alongside opioid medications to induce and maintain unconsciousness and analgesia during surgical procedures.
This is a combination approach using general anesthetic agents alongside opioid medications to induce and maintain unconsciousness and analgesia during surgical procedures. Used for Induction and maintenance of general anesthesia for surgical procedures, Perioperative analgesia and sedation.
At a glance
| Generic name | General anesthesia and opioids |
|---|---|
| Also known as | General anesthesia |
| Sponsor | The Cleveland Clinic |
| Drug class | General anesthetic combination |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
General anesthetics (such as propofol, sevoflurane, or isoflurane) depress the central nervous system to produce unconsciousness, while opioids (such as fentanyl or remifentanil) provide analgesia and contribute to sedation. Together, they enable balanced anesthesia for surgical procedures by targeting multiple pathways of nociception and consciousness.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
- Perioperative analgesia and sedation
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Postoperative cognitive dysfunction
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion (EARLY_PHASE1)
- Comparison of Paravertebral Block and Deep Parasternal Intercostal Plane Block in Cardiac Surgery (NA)
- Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients (PHASE4)
- Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
- Anterior QLB for PCNL (NA)
- Analgesic Techniques for Robotic Prostatectomy Procedures (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- General anesthesia and opioids CI brief — competitive landscape report
- General anesthesia and opioids updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI