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Remifentanil, Propofol, and Desflurane
This is a combination of three anesthetic agents that work together to induce and maintain general anesthesia through different mechanisms: remifentanil provides opioid analgesia, propofol induces sedation via GABA potentiation, and desflurane maintains anesthesia via volatile anesthetic action.
This is a combination of three anesthetic agents that work together to induce and maintain general anesthesia through different mechanisms: remifentanil provides opioid analgesia, propofol induces sedation via GABA potentiation, and desflurane maintains anesthesia via volatile anesthetic action. Used for Induction and maintenance of general anesthesia for surgical procedures.
At a glance
| Generic name | Remifentanil, Propofol, and Desflurane |
|---|---|
| Also known as | Ultiva, Diprivan, Suprane |
| Sponsor | The Cooper Health System |
| Drug class | General anesthetic combination |
| Target | Mu-opioid receptor (remifentanil); GABA-A receptor (propofol); multiple ion channels and neurotransmitter receptors (desflurane) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Remifentanil is a potent synthetic opioid agonist at mu-opioid receptors providing rapid analgesia and sedation. Propofol is a sedative-hypnotic that enhances inhibitory GABA-A receptor signaling in the central nervous system. Desflurane is a volatile anesthetic that modulates multiple ion channels and neurotransmitter receptors to maintain unconsciousness. Together, these agents provide balanced general anesthesia with rapid onset and offset.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Emergence delirium
- Postoperative pain
Key clinical trials
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery (PHASE4)
- Continuous Versus 1-min Oscillometric Arterial BP Monitoring (NA)
- Inhalational Agents Versus Dexmedetomidine for Maintenance of General Anesthesia (NA)
- Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
- Oxidative Stress Effects of TIVA, CIVA, and Balanced Anesthesia in VATS (NA)
- Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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