HIV protease — Drug Target

All drugs that target HIV protease — marketed and clinical-stage. Includes 12 drug classes acting on this target.

Drug classes

Protease inhibitor combination · HIV protease inhibitor (boosted) · HIV protease inhibitor · HIV protease inhibitor combination · Protease inhibitor (boosted) · Protease inhibitor (PI) combination · Protease inhibitor (PI) combination with pharmacokinetic booster · Protease inhibitor · HIV protease inhibitor with pharmacokinetic booster · protease inhibitor · Protease inhibitor with pharmacokinetic booster · Protease inhibitor (PI)

Marketed (34)

• Lopinavir/ritonavir simplification strategy · Fundación Huésped · Protease inhibitor combination · Infectious Disease
  A treatment strategy that simplifies HIV management by optimizing the dosing or administration of lopinavir/ritonavir, a protease inhibitor combination, to improve adherence and reduce pill burden.
• ATV/r · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · HIV protease inhibitor (boosted) · Infectious Disease
  ATV/r is a protease inhibitor boosted with ritonavir that blocks HIV protease, preventing viral replication by inhibiting the cleavage of viral polyproteins.
• Atazanavir ritonavir · Göteborg University · HIV protease inhibitor · Infectious Disease
  Atazanavir is a protease inhibitor that blocks HIV protease, preventing viral polyprotein cleavage and maturation; ritonavir is a booster that inhibits cytochrome P450 metabolism to increase atazanavir levels.
• Darunavir/r · Juan A. Arnaiz · HIV protease inhibitor · Infectious Disease
  Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• Darunavir (DRV/r) · Community Research Initiative of New England · HIV protease inhibitor · Infectious Disease
  Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• Lopinavir / Ritonavir · Baqiyatallah Medical Sciences University · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
• Darunavir ritonavir · St Stephens Aids Trust · HIV protease inhibitor (boosted) · Infectious Disease / Virology
  Darunavir is a protease inhibitor that blocks HIV protease, preventing viral replication, while ritonavir acts as a pharmacokinetic booster to increase darunavir levels.
• Telzir® · ViiV Healthcare · HIV protease inhibitor · Infectious Disease
  Telzir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• Ritonavir (heat-stable) · Bristol-Myers Squibb · HIV protease inhibitor · Infectious Disease
  Ritonavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• Prezista® · Geropharm · HIV protease inhibitor · Infectious Disease
  Prezista (darunavir) is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
• Lopinavir/ritonavir 4:1 · Drugs for Neglected Diseases · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
• Atazanavir (Reyataz) · Germans Trias i Pujol Hospital · HIV protease inhibitor · Infectious Disease
  Atazanavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
• Lopinavir/r plus saquinavir · The HIV Netherlands Australia Thailand Research Collaboration · HIV protease inhibitor combination · Infectious Disease / Virology
  This combination of two protease inhibitors blocks HIV protease to prevent viral replication, with ritonavir boosting lopinavir levels.
• Switch ritonavir-boosted PI · Juan A. Arnaiz · Protease inhibitor (boosted) · Infectious Disease
  A ritonavir-boosted protease inhibitor combination that inhibits HIV protease to prevent viral replication and reduce viral load.
• Saquinavir (Invirase®) · Royal Free Hampstead NHS Trust · HIV protease inhibitor · Infectious Disease
  Saquinavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
• TMC114/ritonavir · Janssen-Cilag Ltd. · HIV protease inhibitor · Infectious Disease
  TMC114 (darunavir) is a protease inhibitor that blocks HIV protease, preventing viral replication when boosted with ritonavir.
• saquinavir/ritonavir · International Antiviral Therapy Evaluation Center · HIV protease inhibitor · Infectious Disease
  Saquinavir and ritonavir are protease inhibitors that block HIV protease, preventing viral replication by inhibiting the cleavage of viral polyproteins.
• ritonavir-boosted fosamprenavir · The University of Texas Health Science Center, Houston · HIV protease inhibitor · Infectious Disease
  Fosamprenavir is a protease inhibitor that blocks HIV protease, preventing viral replication, and is boosted by ritonavir which inhibits its metabolism to increase drug levels.
• Ritonavir (Norvir) · Germans Trias i Pujol Hospital · HIV protease inhibitor · Infectious Disease
  Ritonavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
• Lopinavir/ritonavir and ritonavir · University of Miami · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
• lopinavir with ritonavir in 1:1 ratio · Drugs for Neglected Diseases · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
• Kaletra + Current Dual NRTI Backbone · University of Chicago · Protease inhibitor combination · Infectious Disease
  Kaletra is a protease inhibitor combination that blocks HIV protease to prevent viral replication, used as part of a three-drug antiretroviral regimen with two nucleoside reverse transcriptase inhibitors.
• LPV/r · The HIV Netherlands Australia Thailand Research Collaboration · Protease inhibitor (PI) combination · Infectious Disease / Virology
  LPV/r is a combination of lopinavir and ritonavir that inhibits HIV protease, preventing the maturation of HIV virions and blocking viral replication.
• Darunavir/Ritonavir (Prezista) · Kowa Research Institute, Inc. · HIV protease inhibitor · Infectious Disease
  Darunavir is an HIV protease inhibitor that blocks the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
• Fosamprenavir/ritonavir · ViiV Healthcare · HIV protease inhibitor · Infectious Disease
  Fosamprenavir is a protease inhibitor that blocks HIV protease, preventing viral replication, while ritonavir acts as a pharmacokinetic booster to increase fosamprenavir levels.
• continue on current dual boosted PI · Community Research Initiative of New England · Protease inhibitor (PI) combination with pharmacokinetic booster · Infectious Disease / Virology
  Dual-boosted protease inhibitors block HIV protease to prevent viral replication and reduce viral load in HIV-infected patients.
• protease inhibitors · French National Agency for Research on AIDS and Viral Hepatitis · Protease inhibitor · Infectious Disease / Virology
  Protease inhibitors block the activity of viral proteases, preventing the cleavage of viral polyproteins necessary for viral replication and maturation.
• Reducing dose of Lopinavir · University Hospital, Geneva · HIV protease inhibitor · Infectious Disease
  Lopinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and thereby inhibiting HIV replication.
• Lopinavir/r · Universidade Federal do Rio de Janeiro · Protease inhibitor · Infectious Disease
  Lopinavir/ritonavir is a protease inhibitor combination that blocks HIV protease, preventing viral polyprotein cleavage and maturation.
• Lopinavir and Ritonavir Tablets · DualityBio Inc. · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are HIV protease inhibitors that block the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.
• PEP · Christopher J. McLeod · Protease inhibitor · Infectious disease
  PEP is an antiretroviral medication that inhibits the replication of retroviruses by blocking the action of the viral protease enzyme.
• DRV/r · Community Research Initiative of New England · Protease inhibitor (boosted) · Infectious Disease
  DRV/r is a combination of darunavir (a protease inhibitor) boosted with ritonavir (a pharmacokinetic enhancer) that blocks HIV protease to prevent viral replication.
• Lopinavir/ritonavir (Kaletra) · Abbott · HIV protease inhibitor · Infectious Disease
  Lopinavir and ritonavir are protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
• Active comparator: DRV/cb · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · HIV protease inhibitor with pharmacokinetic booster · Infectious Disease
  DRV/c (darunavir boosted with cobicistat) is a protease inhibitor combined with a pharmacokinetic booster that blocks HIV protease to prevent viral replication.

Phase 3 pipeline (26)

• RBV(24 weeks) · Tanabe Pharma Corporation · protease inhibitor · Infectious Disease
  Ritonavir is a protease inhibitor used to treat HIV/AIDS by preventing the replication of the virus.
• LPV/RTV · ViiV Healthcare · HIV protease inhibitor combination · Infectious Disease
  LPV/RTV is a combination of two protease inhibitors that block HIV protease, preventing the maturation of HIV virions and reducing viral replication.
• fosamprenavir (GW433908) · ViiV Healthcare · Protease inhibitor · Infectious disease
  Fosamprenavir is a prodrug that is metabolized into amprenavir, a protease inhibitor.
• Kaletra Tablets · Ottawa Hospital Research Institute · HIV protease inhibitor combination · Infectious Disease / Virology
  Kaletra is a combination of lopinavir and ritonavir that inhibits HIV protease to prevent viral replication.
• lopinavir or efavirenz · French National Agency for Research on AIDS and Viral Hepatitis · Protease inhibitor · Infectious disease
  Lopinavir is a protease inhibitor that blocks the protease enzyme, preventing viral replication.
• Half-boosted Fosamprenavir · GlaxoSmithKline · HIV protease inhibitor · Infectious Disease
  Half-boosted fosamprenavir is an HIV protease inhibitor that blocks viral protease enzyme activity with reduced ritonavir boosting compared to standard fosamprenavir formulations.
• Indinavir (IDV) · French National Agency for Research on AIDS and Viral Hepatitis · HIV protease inhibitor · Infectious Disease
  Indinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• DRV/COBI FDC · Janssen Research & Development, LLC · Protease inhibitor with pharmacokinetic booster · Infectious Disease
  DRV/COBI is a fixed-dose combination of darunavir (a protease inhibitor) and cobicistat (a pharmacokinetic booster) that inhibits HIV protease to prevent viral replication.
• Darunavir (DRV) · Tibotec Pharmaceuticals, Ireland · HIV protease inhibitor · Infectious Disease
  Darunavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• Nelfinavir (NFV) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · HIV protease inhibitor · Infectious Disease
  Nelfinavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and maturation of infectious HIV particles.
• lopinavir/ritonavir soft gel capsule · Bamrasnaradura Infectious Diseases Institute · Protease inhibitor · Infectious Diseases
  Lopinavir/ritonavir is a combination of two antiretroviral drugs that inhibit the protease enzyme in HIV, preventing viral replication.
• Lopinavir/ritonavir (drug) · Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba · HIV protease inhibitor combination · Infectious Disease
  Lopinavir/ritonavir is a combination protease inhibitor that blocks HIV protease, preventing viral replication by inhibiting the cleavage of viral polyproteins.
• Darunavir/Ritonavir (DRV/r) · Janssen-Cilag S.p.A. · Protease inhibitor (PI) · Infectious Disease / Virology
  Darunavir is a protease inhibitor that blocks HIV protease, preventing viral polyprotein cleavage and maturation, while ritonavir acts as a pharmacokinetic booster to increase darunavir levels.
• darunavir (DRV, TMC114) · Janssen-Cilag International NV · Protease inhibitor · Infectious diseases
  Darunavir is a protease inhibitor that blocks the protease enzyme in HIV, preventing viral replication.
• Atazanavir (immediate switch) · Bristol-Myers Squibb · HIV protease inhibitor · Infectious Disease
  Atazanavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and inhibiting viral replication.
• Atazanavir capsules · Bristol-Myers Squibb · HIV protease inhibitor · Infectious Disease
  Atazanavir inhibits HIV protease, preventing the cleavage of viral polyproteins and blocking the maturation of infectious HIV particles.
• Atazanavir (Week 24 switch) · Bristol-Myers Squibb · HIV protease inhibitor · Infectious Disease
  Atazanavir is a protease inhibitor that blocks HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
• TMC125, Darunavir; Ritonavir · Tibotec, Inc · HIV protease inhibitor · Infectious Diseases
  TMC125, Darunavir; Ritonavir is a combination of HIV protease inhibitors that work by blocking the protease enzyme, preventing the maturation of viral particles.
• TMC114/rtv · Tibotec Pharmaceuticals, Ireland · protease inhibitor · Infectious disease
  TMC114/rtv is a protease inhibitor used to treat HIV infection.
• Atazanavir/ritonavir monotherapy · IRCCS San Raffaele · HIV protease inhibitor · Infectious Disease
  Atazanavir/ritonavir inhibits HIV protease to prevent viral replication, with ritonavir boosting atazanavir levels through CYP3A4 inhibition.
• atazanavir boosted with ritonavir · ANRS, Emerging Infectious Diseases · Protease inhibitor · Infectious diseases
  Atazanavir is a protease inhibitor that blocks the protease enzyme in HIV, preventing the virus from replicating.
• Ritonavir (NRV) · French National Agency for Research on AIDS and Viral Hepatitis · Protease inhibitor · Infectious disease
  Ritonavir is a protease inhibitor that blocks the protease enzyme, preventing viral replication.
• Protease Inhibitor/ritonavir · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia · Protease inhibitor combination · Infectious Disease
  This combination inhibits HIV protease while ritonavir acts as a pharmacokinetic booster to increase protease inhibitor levels in the bloodstream.
• Lopinavir-ritonavir (LPV-RTV) · National Institute of Allergy and Infectious Diseases (NIAID) · Protease inhibitor combination · Infectious Disease
  Lopinavir-ritonavir is a combination of two protease inhibitors that block HIV protease, preventing the cleavage of viral polyproteins and stopping HIV replication.
• TMC-114/RTV · Tibotec Pharmaceuticals, Ireland · Protease inhibitor · Infectious diseases
  TMC-114/RTV is a protease inhibitor used in the treatment of HIV-1 infection.
• Full Boosted Fosamprenavir · GlaxoSmithKline · HIV protease inhibitor · Infectious Disease
  Fosamprenavir is a protease inhibitor that, when boosted with ritonavir, blocks HIV protease to prevent viral replication.

Phase 2 pipeline (1)

• Apomivir® · Far East Bio-Tec Co., Ltd · HIV protease inhibitor · Infectious Disease
  Apomivir is an HIV protease inhibitor that blocks the viral protease enzyme, preventing the maturation of HIV particles and reducing viral replication.