Protease inhibitor
This page covers all Protease inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting SARS-CoV-2 main protease (Mpro), SARS-CoV-2 3CL protease (main protease), SARS-CoV-2 protease enzyme.
Targets
SARS-CoV-2 main protease (Mpro) · SARS-CoV-2 3CL protease (main protease) · SARS-CoV-2 protease enzyme · HIV protease · SARS-CoV-2 main protease · Cytochrome P450 3A4 · Main protease (MPro) of SARS-CoV-2 · UDP-glucuronosyltransferase 1-1 · HIV-1 protease · NS5B polymerase
Marketed (14)
- PF-07321332 Dose 1 · Pfizer
- Nirmatrelvir and ritonavir stage 1 · RenJi Hospital · Infectious Disease / Virology
Nirmatrelvir inhibits the SARS-CoV-2 main protease to prevent viral replication, while ritonavir boosts nirmatrelvir levels by inhibiting its metabolism. - Lexiva · GSK · Immunology
Lexiva works by blocking the protease enzyme, which is necessary for HIV to replicate. - nirmatrelvir-ritonavir · Pfizer · Infectious Disease
- protease inhibitors · French National Agency for Research on AIDS and Viral Hepatitis · Infectious Disease / Virology
Protease inhibitors block the activity of viral proteases, preventing the cleavage of viral polyproteins necessary for viral replication and maturation. - PI · Hoffmann-La Roche · Virology/Infectious Disease
PI is a protease inhibitor that blocks viral protease activity, preventing the maturation and replication of viruses. - Pf-07817883 · Pfizer · Infectious Disease
- Viracept · Agouron Pharms · Immunology
Viracept works by blocking the protease enzyme, which is essential for the replication of HIV. - Protease Inhibitor · Medical Research Council · Infectious Disease
Protease inhibitors block viral or bacterial protease enzymes, preventing the processing of viral or pathogenic proteins necessary for replication and survival. - PF-07321332 Dose 5 · Pfizer
- Agenerase · GSK · Immunology
- Lopinavir/r · Universidade Federal do Rio de Janeiro · Infectious Disease
Lopinavir/ritonavir is a protease inhibitor combination that blocks HIV protease, preventing viral polyprotein cleavage and maturation. - PEP · Christopher J. McLeod · Infectious disease
PEP is an antiretroviral medication that inhibits the replication of retroviruses by blocking the action of the viral protease enzyme. - Reyataz · Bristol-Myers Squibb · Immunology
Reyataz works by blocking the protease enzyme, which is essential for the replication of HIV.
Phase 3 pipeline (18)
- darunavir (DRV, TMC114) · Janssen-Cilag International NV · Infectious diseases
Darunavir is a protease inhibitor that blocks the protease enzyme in HIV, preventing viral replication. - lopinavir or efavirenz · French National Agency for Research on AIDS and Viral Hepatitis · Infectious disease
Lopinavir is a protease inhibitor that blocks the protease enzyme, preventing viral replication. - fosamprenavir (GW433908) · ViiV Healthcare · Infectious disease
Fosamprenavir is a prodrug that is metabolized into amprenavir, a protease inhibitor. - continue the PI/r-containing HAART. · ASST Fatebenefratelli Sacco · Infectious disease
Ritonavir is a protease inhibitor used to treat HIV-1 infection by preventing the replication of the virus. - TVR · Janssen R&D Ireland · Infectious diseases
TVR is a protease inhibitor that works by blocking the replication of the hepatitis C virus. - Placebo to vaniprevir · Merck Sharp & Dohme LLC · Infectious Diseases
Vaniprevir is a protease inhibitor that targets the hepatitis C virus. - TMC114/rtv · Tibotec Pharmaceuticals, Ireland · Infectious disease
TMC114/rtv is a protease inhibitor used to treat HIV infection. - TMC435 · Tibotec Pharmaceuticals, Ireland · Infectious Diseases
TMC435 is a protease inhibitor used to treat HIV-1 infection. - atazanavir boosted with ritonavir · ANRS, Emerging Infectious Diseases · Infectious diseases
Atazanavir is a protease inhibitor that blocks the protease enzyme in HIV, preventing the virus from replicating. - Placebo to Boceprevir · Merck Sharp & Dohme LLC · Infectious Disease
Boceprevir is a protease inhibitor that works by blocking the replication of the hepatitis C virus. - RBV(24 weeks) · Tanabe Pharma Corporation · Infectious Disease
Ritonavir is a protease inhibitor used to treat HIV/AIDS by preventing the replication of the virus. - lopinavir/ritonavir soft gel capsule · Bamrasnaradura Infectious Diseases Institute · Infectious Diseases
Lopinavir/ritonavir is a combination of two antiretroviral drugs that inhibit the protease enzyme in HIV, preventing viral replication. - lopinavir/ritonavir (LPV/r) · French National Agency for Research on AIDS and Viral Hepatitis · Infectious disease
Lopinavir/ritonavir is a protease inhibitor used to treat HIV-1 infection by preventing the replication of the virus. - Placebo Narlaprevir · R-Pharm · Infectious Diseases
Narlaprevir is a protease inhibitor used to treat hepatitis C virus (HCV) infection. - TMC114 · Tibotec Pharmaceuticals, Ireland · Infectious Diseases
TMC114 is a protease inhibitor used to treat HIV-1 infection. - Ritonavir (NRV) · French National Agency for Research on AIDS and Viral Hepatitis · Infectious disease
Ritonavir is a protease inhibitor that blocks the protease enzyme, preventing viral replication. - Tipranavir/Ritonavir · Johns Hopkins University · Infectious disease
Tipranavir/Ritonavir is a protease inhibitor used in combination with other medications to treat HIV-1 infection. - TMC-114/RTV · Tibotec Pharmaceuticals, Ireland · Infectious diseases
TMC-114/RTV is a protease inhibitor used in the treatment of HIV-1 infection.